| Author | Lelis, Deborah de Farias | |
| Author | Baldo, Thaís de Oliveira Faria | |
| Author | Andrade, João Marcus Oliveira | |
| Author | Griep, Rosane Harter | |
| Author | Bensenor, Isabela Judith Martins | |
| Author | Lotufo, Paulo Andrade | |
| Author | Mill, José Geraldo | |
| Author | Baldo, Marcelo Perim | |
| Access date | 2024-10-24T17:17:52Z | |
| Available date | 2024-10-24T17:17:52Z | |
| Document date | 2024 | |
| Citation | LELIS, Deborah de Farias et al. High triglyceride-glucose index and HOMA-IR are associated with different cardiometabolic profile in adults from the ELSA-Brasil study. Clinical Biochemistry, v. 131-132, p. 1-7, Oct. 2024. | |
| ISSN | 0009-9120 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66721 | |
| Description | Produção científica do Laboratório de Educação em Ambiente e Saúde. | pt_BR |
| Sponsorship | The ELSA-Brasil study was supported by the Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP, Financiadora de Estudos e Projetos), grants no. 01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00 and 01 06 0071.00 and CNPq (the National Council for Scientific and Technological Development). | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | High triglyceride-glucose index and HOMA-IR are associated with different cardiometabolic profile in adults from the ELSA-Brasil study | en_US |
| Type | Article | |
| DOI | 10.1016/j.clinbiochem.2024.110793 | |
| Abstract | Background and aims: Insulin resistance (IR) is a risk factor for several cardiometabolic disorders; however, there is conflicting evidence about the reliability of certain IR markers. In this context, the triglyceride-glucose index (TyG) has been proposed as a surrogate marker for IR. This study aimed to compare the TyG index and homeostasis model assessment of insulin resistance (HOMA-IR). Methods and results: A cross-sectional analysis was conducted using baseline data from 11,314 adults (aged 35–74 years) from the ELSA-Brasil study. The correlation between TyG and HOMA-IR, their interrater reliability, and their predictive value in identifying metabolic syndrome (MetS) were assessed. The mean TyG and HOMA-IR in our sample were 8.81 ± 0.52 and 2.78 ± 1.58 for men, and 8.53 ± 0.48 and 2.49 ± 1.38 for women, respectively. TyG and HOMA-IR showed a weak to moderate correlation with each other (Pearson’s r for men: 0.395 and 0.409 for women, p-value <0.05) and other markers of glycemic metabolism. Additionally, the area under the curve for the prediction of MetS was greater for TyG than HOMA-IR, regardless of sex (TyG: 0.836 for men and 0.826 for women; HOMA-IR: 0.775 for men and 0.787 for women). The concordance between these markers was low (Coheńs kappa coefficient: 0.307 for men and 0.306 for women). Individuals with increased TyG exhibited mainly anthropometrical and glycemic metabolic alterations, whereas those with elevated HOMA-IR displayed mostly lipid-associated metabolic alterations. Conclusion: TyG and HOMA-IR might indicate different profiles of cardiometabolic disorders, showing poor agreement in classifying individuals (normal vs. altered) and a weak correlation. Therefore, further studies are needed to investigate the role of TyG as a surrogate marker of IR. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Centro Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Affilliation | Universidade Estadual de Montes Claros. Centro Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Affilliation | Universidade Estadual de Montes Claros. Centro Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | |
| Affilliation | Universidade Estadual de Montes Claros. Centro Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Subject | Insulin resistance | en_US |
| Subject | Metabolic syndrome | en_US |
| Subject | Triglyceride-glucose index | en_US |
| Subject | Homeostasis model assessment of insulin | en_US |
| Subject | Resistance | en_US |
| e-ISSN | 1873-2933 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
