| Author | Leles, Lorena Ferreira de Oliveira | |
| Author | Alvarez, Marcus Vinicius Niz | |
| Author | Carvajal Cortes, Jose Joaquin | |
| Author | Alonso, Diego Peres | |
| Author | Ribolla, Paulo Eduardo Martins | |
| Author | Luz, Sérgio Luiz Bessa | |
| Access date | 2024-10-31T18:12:37Z | |
| Available date | 2024-10-31T18:12:37Z | |
| Document date | 2024 | |
| Citation | LELES, Lorena Ferreira de Oliveira et al. Impact of long-term Pyriproxyfen exposure on the genetic structure and diversity of Aedes aegypti and Aedes albopictus in Manaus, Amazonas, Brazil. Genes, v. 15, n. 8, p. 1-13, 8 Aug. 2024. | |
| ISSN | 2073-4425 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66836 | |
| Sponsorship | This research was funded by the Coordenação-Geral de Vigilância de Arboviroses, Secretaria de Vigilância em Saúde e Ambiente, project "Controle de Aedes spp. com Estações disseminadoras de Larvicida" (TED-037-250000.076894/2016-13), Ministry of Health, Brazil. | |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | Impact of long-term Pyriproxyfen exposure on the genetic structure and diversity of Aedes aegypti and Aedes albopictus in Manaus, Amazonas, Brazil | en_US |
| Type | Article | |
| DOI | 10.3390/genes15081046 | |
| Abstract | Aedes aegypti and Aedes albopictus are responsible for transmitting major human arboviruses such as Dengue, Zika, and Chikungunya, posing a global threat to public health. The lack of etiological treatments and efficient vaccines makes vector control strategies essential for reducing vector population density and interrupting the pathogen transmission cycle. This study evaluated the impact of long-term pyriproxyfen exposure on the genetic structure and diversity of Ae. aegypti and Ae. albopictus mosquito populations. The study was conducted in Manaus, Amazonas, Brazil, where pyriproxyfen dissemination stations have been monitored since 2014 up to the present day. Double digest restriction-site associated DNA sequencing was performed, revealing that despite significant local population reductions by dissemination stations with pyriproxyfen in various locations in Brazil, focal intervention has no significant impact on the population stratification of these vectors in urban scenarios. The genetic structuring level of Ae. aegypti suggests it is more stratified and directly affected by pyriproxyfen intervention, while for Ae. albopictus exhibits a more homogeneous and less structured population. The results suggest that although slight differences are observed among mosquito subpopulations, intervention focused on neighborhoods in a capital city is not efficient in terms of genetic structuring, indicating that larger-scale pyriproxyfen interventions should be considered for more effective urban mosquito control. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Biociências. Laboratório de Pesquisa em Análises Genéticas. Botucatu, SP, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil. | |
| Affilliation | Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Biociências. Laboratório de Pesquisa em Análises Genéticas. Botucatu, SP, Brasil. | |
| Affilliation | Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Biociências. Laboratório de Pesquisa em Análises Genéticas. Botucatu, SP, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Subject | Aedes aegypti | en_US |
| Subject | Aedes albopictus | en_US |
| Subject | Pyriproxyfen | en_US |
| Subject | ddRADseq | en_US |
| Subject | Genomic surveillance | en_US |
| e-ISSN | 2073-4425 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 11 Cidades e comunidades sustentáveis | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
