| Author | Barreto-Duarte, Beatriz | |
| Author | Villalva-Serra, Klauss | |
| Author | Miguez-Pinto, João P. | |
| Author | Araújo-Pereira, Mariana | |
| Author | Campos, Vanessa M. S. | |
| Author | Rosier, Gabriela | |
| Author | Nogueira, Betânia M. F. | |
| Author | Queiroz, Artur T. L. | |
| Author | Rolla, Valeria Cavalcanti | |
| Author | Cordeiro-Santos, Marcelo | |
| Author | Kritski, Afrânio L. | |
| Author | Martinez, Leonardo | |
| Author | Rebeiro, Peter F. | |
| Author | Sterling, Timothy R. | |
| Author | Rodrigues, Moreno M. | |
| Author | Andrade, Bruno B. | |
| Access date | 2024-11-26T13:18:03Z | |
| Available date | 2024-11-26T13:18:03Z | |
| Document date | 2024 | |
| Citation | BARRETO-DUARTE, Beatriz et al. Retreatment and Anti-tuberculosis Therapy Outcomes in Brazil Between 2015 and 2022: A Nationwide Study. Open Forum Infectious Diseases, v. 11, n. 8, p. 1-9, Jul. 2024. | en_US |
| ISSN | 2328-8957 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67279 | |
| Sponsorship | Programa de Pesquisa Intramuros da Fundação Oswaldo Cruz. Programa Intramuros de Investigação da Fundação José Silveira.
Departamento de Ciência e Tecnologia, Secretaria de Ciência e Tecnologia, Ministério da Saúde, Brasil. US National Institute of Allergy and Infectious Diseases. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). | en_US |
| Sponsorship | The study was supported by the Intramural Research Program of the Fundação Oswaldo Cruz (to B. B. A.); Intramural Research Program of the Fundação José Silveira (to B. B. A.); Departamento de Ciência e Tecnologia, Secretaria de Ciência e Tecnologia, Ministério da Saúde, Brazil (25029.000507/2013-07 to V. C. R.); and the US National Institute of Allergy and Infectious Diseases (U01-AI069923 to T. R. S., M. B. A., V. C. R., A. L. K., T. R. S., B. B. A., and M. C.-S.). B. B. D. received a fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. B. B. A., V. C. R., M. C.-S., and A. L. K. are senior investigators and fellows from the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil. A. L. K. is a recipient of the Scientist of Our State fellowship from Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (Rio de Janeiro Research Council). | |
| Language | eng | en_US |
| Publisher | Oxford | en_US |
| Rights | open access | en_US |
| Title | Retreatment and anti-tuberculosis therapy outcomes in Brazil between 2015 and 2022: a nationwide study | en_US |
| Type | Article | en_US |
| DOI | 10.1093/ofid/ofae416 | |
| Abstract | Background: Adherence to anti-tuberculosis treatment (ATT) in Brazil remains a challenge in achieving the goals set by the World Health Organization (WHO). Patients who are lost to follow-up during treatment pose a significant public health problem. This study aimed to investigate the factors associated with unfavorable ATT outcomes among those undergoing retreatment in Brazil. Methods: We conducted an observational study of patients aged ≥18 years with tuberculosis (TB) reported to the Brazilian National Notifiable Disease Information System between 2015 and 2022. Clinical and epidemiologic variables were compared between the study groups (new cases and retreatment). Regression models identified variables associated with unfavorable outcomes. Results: Among 743 823 reported TB cases in the study period, 555 632 cases were eligible, consisting of 462 061 new cases and 93 571 undergoing retreatments (44 642 recurrent and 48 929 retreatments after loss to follow-up [RLTFU]). RLTFU (odds ratio [OR], 3.96 [95% confidence interval {CI}, 3.83-4.1]) was a significant risk factor for any type of unfavorable ATT. Furthermore, RLTFU (OR, 4.93 [95% CI, 4.76-5.11]) was the main risk factor for subsequent LTFU. For death, aside from advanced age, living with HIV (OR, 6.28 [95% CI, 6.03-6.54]) was the top risk factor. Conclusions: Retreatment is a substantial risk factor for unfavorable ATT outcomes, especially after LTFU. The rates of treatment success in RLTFU are distant from the WHO End TB Strategy targets throughout Brazil. These findings underscore the need for targeted interventions to improve treatment adherence and outcomes in persons who experience RLTFU. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Pós-Graduação de Clínica Médica. Rio de Janeiro, RJ, Brasil / Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Clariens Educação. Faculdade Zarns. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | en_US |
| Affilliation | Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Clariens Educação. Faculdade Zarns. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | en_US |
| Affilliation | Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Clariens Educação. Faculdade Zarns. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Clariens Educação. Faculdade Zarns. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Medicina Tropical Doutor Heitor Vieira Dourado. Departamento de Tuberculose. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Pós-Graduação de Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Boston University. School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA. | en_US |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA. | en_US |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA. | en_US |
| Affilliation | Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Análise e Visualização de Dados. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Pós-Graduação de Clínica Médica. Rio de Janeiro, RJ, Brasil / Institute for Research in Priority Populations. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Clariens Educação. Faculdade Zarns. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA. | en_US |
| Subject | Epidemiology | en_US |
| Subject | Loss to follow-up | en_US |
| Subject | Retreatment | en_US |
| Subject | Treatment outcome | en_US |
| Subject | Tuberculosis | en_US |
| DeCS | Epidemiologia | en_US |
| DeCS | Retratamento | en_US |
| DeCS | Resultado do tratamento | en_US |
| DeCS | Tuberculose | en_US |
| e-ISSN | 2328-8957 | |
