| Author | Ferreira, Isabella B. B. | |
| Author | Gomes, Alexvon N. | |
| Author | Almeida, Isadora B. C. | |
| Author | Fernandes, Mariana D. | |
| Author | Coutinho, Ludmilla F. | |
| Author | Lago, Renata | |
| Author | Menezes, Camilla A. | |
| Author | Vianna, Nelzair A. | |
| Author | Oliveira, Ricardo R. | |
| Author | Fukutani, Eduardo R. | |
| Author | Menezes, Rodrigo C. | |
| Author | Ladeia, Ana Marice | |
| Author | Andrade, Bruno B. | |
| Access date | 2024-11-28T11:48:46Z | |
| Available date | 2024-11-28T11:48:46Z | |
| Document date | 2024 | |
| Citation | FERREIRA, Isabella B. B. et al. Childhood obesity is associated with a high degree of metabolic disturbance in children from Brazilian semi‑arid region. Scientific Reports, v. 14, n.1, p. 1-7, 2024. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67325 | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Ministério Público do Estado da Bahia, Programa Escola Sustentável. | en_US |
| Language | eng | en_US |
| Publisher | Nature Research | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Crianças | en_US |
| Subject in Portuguese | Obesidade | en_US |
| Subject in Portuguese | Distúrbios metabólicos | en_US |
| Subject in Portuguese | Semiárido brasileiro | en_US |
| Title | Childhood obesity is associated with a high degree of metabolic disturbance in children from Brazilian semi‑arid region | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41598-024-68661-8 | |
| Abstract | Projected to impact 310 million children by the next decade, childhood obesity is linked to serious health issues like metabolic disturbance and cardiovascular diseases. This study introduces a novel approach for the integrated assessment of inflammatory, glycemic and lipid disorders in obese children in resources-limited settings and also identifies key factors contributing to these changes. Conducting a cross-sectional analysis of 231 children aged 5-12 years from public schools in Brazil's semi-arid region, the research involved collecting medical history, anthropometric measurements, and blood samples to analyze glycemic and lipid profiles, along with C-reactive protein levels. We used an adapted the Molecular Degree of Perturbation model to analyze deviations in metabolic markers from a healthy control group. Statistical analyses included Mann-Whitney and Fisher exact tests, backward logistic regression, and hierarchical cluster analysis. The study identified a direct and independent association between elevated Metabolic Disturbance Degree and both overweight and obesity in children, with significant differences in CRP, Triglycerides, and HDL levels noted between obese and healthy-weight groups. The findings highlight the critical need for early detection and comprehensive understanding of obesity-related changes to mitigate the severe health risks associated with childhood obesity. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Programa de Pós‑Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Affilliation | Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Subject | Children | en_US |
| Subject | Obesity | en_US |
| Subject | Metabolic disturbance | en_US |
| Subject | Brazilian semi-arid region | en_US |
| DeCS | Criança | en_US |
| DeCS | Obesidade pediátrica | en_US |
