| Author | Lopes, Dhara Leite | |
| Author | Villarreal, Cristiane Flora | |
| Author | Opretzka, Luiza Carolina França | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Silva, Marcelo Sobral da | |
| Author | Barbosa Filho, José Maria | |
| Author | Juiz, Paulo José Lima | |
| Access date | 2024-11-28T15:10:53Z | |
| Available date | 2024-11-28T15:10:53Z | |
| Document date | 2024 | |
| Citation | LOPES, Dhara Leite et al. The effects of fraxetin and monnieriside A on Cultured L929 fibroblasts. Natural Product Research, v. 17, p. 1-6, 2024. | en_US |
| ISSN | 1478-6427 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67338 | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | Taylor and Francis Group | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Fibroblasto | en_US |
| Subject in Portuguese | Bioativo | en_US |
| Subject in Portuguese | Fraxetina | en_US |
| Subject in Portuguese | Monnieriside A | en_US |
| Subject in Portuguese | Arranhão | en_US |
| Subject in Portuguese | Cicatrizante de feridas | en_US |
| Title | The effects of fraxetin and monnieriside A on Cultured L929 fibroblasts | en_US |
| Type | Article | en_US |
| DOI | 10.1080/14786419.2024.2368268 | |
| Abstract | Skin lesions are considered a public health problem, compromising patients' quality of life. This work aimed to evaluate the effects of fraxetin and monnieriside A on Cultured L929 Fibroblasts through the scratch assay. Supernatants and cells from the fibroblast culture treated with the compounds were used to evaluate essential markers of the tissue repair process (IGF-1, VEGF, IL-8, IL-10, FGF-2, COL1A2, COL4A, PDGF) using ELISA and qRT-PCR. The results showed that fraxetin and MOA were non-cytotoxic and could stimulate cellular migration. Fraxetin induced IGF-1, VEGF, IL-8, and IL-10 expression, while MOA induced FGF2, COL1A2, and IL-10 expression. Altogether, these results set provides evidence that fraxetin and MOA have healing potential for tissue repair, paving the way for in vivo studies and clinical trials to validate the in vitro results. | en_US |
| Affilliation | Universidade Estadual de Feira de Santana. Departamento de Biologia. Feira de Santana, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Departamento de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Departamento de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Sistemas Avançados de Saúde (ISI-SAS). Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Paraíba. Departamento de Pesquisa em Drogas e Medicamentos. João Pessoa, PB, Brasil. | en_US |
| Affilliation | Universidade Federal do Recôncavo da Bahia. Centro de Ciência e Tecnologia em Energia e Sustentabilidade (CETENS). Feira de Santana, BA, Brasil. | en_US |
| Subject | Fibroblast | en_US |
| Subject | Bioactive | en_US |
| Subject | Fraxetine | en_US |
| Subject | Monnieriside A | en_US |
| Subject | Scratch | en_US |
| Subject | Wound healing | en_US |
| DeCS | Cicatrização | en_US |
| DeCS | Fibroblastos | en_US |
| Embargo date | 2027 | |
