| Author | Passos, Fabine Correia | |
| Author | Oliveira, Lucas Matheus Gonçalves | |
| Author | Jesus, Fabíola Ramos | |
| Author | Zanette, Dalila Lucíola | |
| Author | Leal Neto, Odilon Lobão | |
| Author | Neves, Margarida Célia Lima Costa | |
| Author | Lemos, Antônio Carlos Moreira | |
| Author | Baccan, Gyselle Chrystina | |
| Access date | 2024-12-07T12:37:49Z | |
| Available date | 2024-12-07T12:37:49Z | |
| Document date | 2024 | |
| Citation | PASSOS, F. C. et al. Beneficial bacteria in the gut microbiota may lead to improved metabolic and immunological status in chronic obstructive pulmonary disease. Medical Sciences, v. 12, n. 41, p. 1-14, 2024. | en_US |
| ISSN | 2076-3271 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67457 | |
| Description | The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Professor Edgar Santos University Hospital Complex—Federal University of Bahia (HUPES-UFBA) (protocol no. CAAE: 4.045.818/
February 2020). | en_US |
| Sponsorship | FAPESB, Universidade Federal da Bahia (PERMANECER Program- ed 2018 Projeto nº 14128) | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Doença pulmonar obstrutiva crônica | en_US |
| Subject in Portuguese | Citocinas | en_US |
| Subject in Portuguese | Microbiota intestinal | en_US |
| Subject in Portuguese | Marcadores clínicos | en_US |
| Title | Beneficial bacteria in the gut microbiota may lead to improved metabolic and immunological status in chronic obstructive pulmonary disease | en_US |
| Type | Article | en_US |
| DOI | 10.3390/medsci12030041 | |
| Abstract | The progression of chronic obstructive pulmonary disease (COPD) is characterized by functional changes in the airways. The lung–gut axis and gut microbiota (GM) have been linked to the pathophysiology of airway diseases. Regarding COPD, studies have shown that GM alterations could be related the stages of this disease. However, the relationship between GM and clinical, biochemical and immunological parameters in patients with COPD are not well understood. The aim of this study was to compare the relative abundance of specific groups of beneficial gut bacteria between COPD patients and healthy controls (CTLs) in order to evaluate relationships with metabolic and inflammatory markers in COPD. Methods: We included 16 stable COPD patients and 16 healthy volunteer CTLs. The relative abundances of Bifidobacterium spp. (Bf) and Akkermansia muciniphila (Akk) bacteria and the Bacteroidetes and Firmicutes phyla were assessed by qPCR. Pulmonary function was evaluated by spirometry, biochemical parameters by colorimetric methods and plasma cytokine levels by cytometric bead array analysis. Results: The Firmicutes/Bacteroides ratio was related to emergency hospital visits and six-minute walk test (6MWT) results. Furthermore, the relative abundance of Bf was associated with plasma concentrations of glucose, triglycerides, HDL-C and IL-10. In addition, Firmicutes levels and the Firmicutes/Bacteroidetes ratio were associated with the IL-12/IL-10 ratio, while Akk abundance was linked to IL-12 levels. Conclusions: The present findings suggest that the abundance of beneficial bacteria in the GM could influence clinical presentation and immunoregulation in COPD. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Maternidade Climério de Oliveira. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Ambulatório Professor Francisco Magalhães Neto. Unidade do Sistema Respiratório. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Ambulatório Professor Francisco Magalhães Neto. Unidade do Sistema Respiratório. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
| Subject | Chronic obstructive pulmonary disease | en_US |
| Subject | Gut microbiota | en_US |
| Subject | cytokines | en_US |
| Subject | Clinical markers | en_US |
