| Author | Bochnia-Bueno, Lucas | |
| Author | Coelho, Gabriela Mattoso | |
| Author | Cataneo, Allan Henrique Depieri | |
| Author | Zanluca, Camila | |
| Author | Ferreira, Laura Holtman | |
| Author | Cavalcanti, Luciano Pamplona de Goes | |
| Author | Clementino, Marco Antonio de Freitas | |
| Author | Yaochite, Juliana Navarro Ueda | |
| Author | Santos, Hellen Geremias | |
| Author | Nogueira, Meri Bordignon | |
| Author | Santos, Claudia Nunes Duarte | |
| Author | Raboni, Sonia Mara | |
| Access date | 2024-12-07T16:30:25Z | |
| Available date | 2024-12-07T16:30:25Z | |
| Document date | 2024 | |
| Citation | BOCHNIA-BUENO, L. et al. Asessment of immune responses to a Comirnaty® booster following CoronaVac® vaccination in healthcare workers. Memórias do Instituto Oswaldo Cruz, v. 119, n. e230239, p. 1-9, 2024. | en_US |
| ISSN | 1678-8060 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67458 | |
| Sponsorship | PROPLAN/UFPR, FINEP, Ministério da Saúde, CNPq, Fundação Araucária, SESA-PR (PPSUS 2020/2021) (grants ICC-004-FEX-21
and 027/2021); CAPES (grant 88881.504691/2020-01); JBS S.A (“Fazer o Bem Faz Bem” Program), CNPq | en_US |
| Language | eng | en_US |
| Publisher | IOC | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Pandemia | en_US |
| Subject in Portuguese | Vacina | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Resposta imune | en_US |
| Subject in Portuguese | Imunização | en_US |
| Subject in Portuguese | Saúde pública | en_US |
| Title | Assessment of immune responses to a Comirnaty® booster following CoronaVac® vaccination in healthcare workers | en_US |
| Type | Article | en_US |
| DOI | 10.1590/0074-02760230239 | |
| Abstract | BACKGROUND The immunological response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and immunisation is variable.
OBJECTIVES To describe the humoral immune response by correlating IgA and IgG antibodies with NAbs titration following CoronaVac® immunisation and an mRNA (Comirnaty®) booster among healthcare workers (HCWs) and to compare the cytokine and interleukin profiles between HCWs vaccinated with CoronaVac and coronavirus disease 2019 (COVID-19) infected patients.
METHODS Samples from 133 HCWs collected at 20 (T1) and 90 (T2) days after CoronaVac immunisation and 15 (T3) days after a booster dose with the Comirnaty vaccine were analysed for IgA and IgG EIA and neutralisation assay. Cytokine levels from vaccinated individuals at T1 day and COVID-19 patients were compared.
FINDINGS Neutralising antibodies (NAbs) were observed in 81.7% of participants at T1, but only 49.2% maintained detectable NAbs after 90 days. The booster dose increased NAbs response in all participants. The cytokines with the highest levels post-vaccination were IL-6 and MCP-1. The MCP-1, IL-18, and IFN- γ levels were higher in COVID-19 patients than in vaccinated HCWs, while IL-22 levels increased in the vaccinated HCWs group.
MAIN CONCLUSIONS The neutralisation titres in the T2 samples decreased, and antibody levels detected at T2 showed a more significant reduction than the neutralisation. The higher IL-22 expression in immunised individuals compared to those with COVID-19 suggests that IL-22 may be beneficial in protecting against severe disease. | en_US |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil / Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil / Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Universidade Federal do Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Universidade Federal do Ceará. Faculdade de Farmácia, Odontologia e Enfermagem. Departamento de Análises Clínicas e Toxicologia. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil / Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Vaccine | en_US |
| Subject | Immune response | en_US |
| Subject | Immunisation | en_US |
| Subject | Public health | en_US |
| Subject | Pandemic | en_US |
| DeCS | Saúde pública | en_US |
| DeCS | Vacinas | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | Imunidade | en_US |
| DeCS | Pandemias | en_US |
