| Author | Macêdo, Carolina Thé | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Villarreal, Cristiane Flora | |
| Author | Silva, Daniela Nascimento | |
| Author | Silva, Kátia Nunes da | |
| Author | Souza, Clarissa Lima e Moura de | |
| Author | Paixão, Daniela da Silva | |
| Author | Bezerra, Milena da Rocha | |
| Author | Costa, Antônio Olímpio da Silva Moura | |
| Author | Brazão, Eduardo Santos | |
| Author | Marins Filho, Josildo Pereira | |
| Author | Matos, André Costa | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2024-12-09T11:58:05Z | |
| Available date | 2024-12-09T11:58:05Z | |
| Document date | 2024 | |
| Citation | MACEDO, Carolina Thé et al. Transplantation of autologous mesenchymal stromal ells in complete cervical spinal cord injury: a pilot study. Frontiers in Medicine, v. 11, p. 1-7, 2024. | en_US |
| ISSN | 2296-858X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67468 | |
| Sponsorship | Banco Nacional de Desenvolvimento Econômico e Social (BNDES). | en_US |
| Language | eng | en_US |
| Publisher | Frontiers Media | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Célula-tronco | en_US |
| Subject in Portuguese | Lesão da medula espinhal | en_US |
| Subject in Portuguese | Terapia celular | en_US |
| Subject in Portuguese | Células estromais mesenquimais (MSC) | en_US |
| Subject in Portuguese | Tetraplegia | en_US |
| Title | Transplantation of autologous mesenchymal stromal ells in complete cervical spinal cord injury: a pilot study | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fmed.2024.1451297 | |
| Abstract | Objective: Spinal cord injury (SCI) is a serious condition that can lead to partial or complete paraplegia or tetraplegia. Currently, there are few therapeutic options for these conditions, which are mainly directed toward the acute phase, such as surgical intervention and high-dose steroid administration. Mesenchymal stromal cells (MSC) have been shown to improve neurological function following spinal cord injury. The aim of the study was to evaluate the safety, feasibility, and potential efficacy of MSC transplantation in patients with cervical traumatic SCI. Methods: We included seven subjects with chronic traumatic SCI (> 1 year) at the cervical level, classified as American Spinal Cord Injury Association impairment scale (AIS) grade A. Subjects received two doses of autologous bone marrow derived MSC, the first by direct injection into the lesion site after hemilaminectomy and the second three months later by intrathecal injection. Neurologic evaluation, spinal magnetic resonance imaging (MRI), urodynamics, and life quality questionnaires were assessed before and after treatment. Results: Cell transplantation was safe without severe or moderate adverse effects, and the procedures were well tolerated. Neurological evaluation revealed discrete improvements in sensitivity below the lesion level, following treatment. Five subjects showed some degree of bilateral sensory improvement for both superficial and deep mechanical stimuli compared to the pretreatment profile. No significant alterations in bladder function were observed during this study. Conclusion: Transplantation of autologous MSC in patients with chronic cervical SCI is a safe and feasible procedure. Further studies are required to confirm the efficacy of this therapeutic approach. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC, Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC, Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC, Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC, Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Stem cell | en_US |
| Subject | Spinal cord injury | en_US |
| Subject | Cellular therapy | en_US |
| Subject | Mesenchymal stromal cells (MSC) | en_US |
| Subject | Tetraplegia | en_US |
| DeCS | Células-tronco | en_US |
| DeCS | Medula espinal | en_US |
| DeCS | Terapia baseada em transplante de células e tecidos | en_US |
| DeCS | Células-tronco mesenquimais | en_US |
| DeCS | Quadriplegia | en_US |
