| Author | Calderaro, Débora Cerqueira | |
| Author | Valim, Valéria | |
| Author | Ferreira, Gilda Aparecida | |
| Author | Machado, Ketty Lysie Libardi Lira | |
| Author | Ribeiro, Priscila Dias Cardoso | |
| Author | Ribeiro, Sandra Lúcia Euzébio | |
| Author | Sartori, Natalia Sarzi | |
| Author | Rezende, Rodrigo Poubel Vieira de | |
| Author | Melo, Ana Karla Guedes de | |
| Author | Cruz, Vitor Alves | |
| Author | Vieira, Adah Sophia Rodrigues | |
| Author | Kakehasi, Adriana Maria | |
| Author | Landa, Aline Teixeira de | |
| Author | Burian, Ana Paula Neves | |
| Author | Peixoto, Flávia Maria Matos Melo Campos | |
| Author | Telles, Camila Maria Paiva França | |
| Author | Santo, Rafaela Cavalheiro do Espírito | |
| Author | Baptista, Katia Lino | |
| Author | Oliveira, Yasmin Gurtler Pinheiro de | |
| Author | Magalhães, Vanessa de Oliveira | |
| Author | Lima, Raquel Lima de | |
| Author | Biegelmeyer, Erika | |
| Author | Lorencini, Pietra Zava | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Reis-Neto, Edgard Torres Dos | |
| Author | Sato, Emília Inoue | |
| Author | Pinheiro, Marcelo de Medeiros | |
| Author | Monticielo, Odirlei André | |
| Author | Souza, Viviane Angelina de | |
| Author | Xavier, Ricardo Machado | |
| Author | Pileggi, Gecilmara Salviato | |
| Author | SAFER-Study Group Task Force | |
| Access date | 2024-12-09T16:24:29Z | |
| Available date | 2024-12-09T16:24:29Z | |
| Document date | 2024 | |
| Citation | CALDERARO, Débora Cerqueira et al. Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from SAFER-Study. Vaccines, v. 12, n. 9, 1031, 2024. doi: 10.3390/vaccines12091031. | en_US |
| ISSN | 2076-393x | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67481 | |
| Language | eng | en_US |
| Publisher | MPDI | en_US |
| Rights | open access | en_US |
| Title | Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from SAFER-Study | en_US |
| Type | Article | en_US |
| Abstract | Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough COVID-19 occurring in IMRD patients participating in the SAFER-study, a Brazilian multicentric cohort evaluating the safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines in patients with autoimmune diseases. A descriptive analysis of the population and a binary logistic regression model were performed to evaluate the predictors of COVID-19-related hospitalization. A p-value < 0.05 was significant. The included 160 patients were predominantly females (83.1%), with a mean (SD) age of 40.23 (13.19) years. The patients received two (19%), three (70%), or four (11%) vaccine doses. The initial two-dose series was mainly with ChAdOx1 (Oxford/AstraZeneca) (58%) or BBIBP-CorV (Sinopharm-Beijing) (34%). The first booster (n = 150) was with BNT162b2 (BioNtech/Fosun Pharma/Pfizer) (63%) or ChAdOx1 (29%). The second booster (n = 112) was with BNT162b2 (40%) or ChAdOx1 (26%). The COVID-19 hospitalization rate was 17.5%. IMRD moderate/high activity (OR: 5.84; CI: 1.9-18.5; p = 0.002) and treatment with corticosteroids (OR: 2.94; CI: 1.02-8.49; p = 0.0043) were associated with higher odds of hospitalization, while increasing the number of vaccine doses was protective (OR: 0.37; CI: 0.15-0.9; p = 0.032). These findings, along with previous reassuring results about the safety of the COVID-19 vaccines, argue in favor of booster vaccination in IMRD patients. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento do Sistema Locomotor. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento do Sistema Locomotor. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Escola de Medicina. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Universidade Federal Fluminense. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal da Paraíba. Hospital Universitário Lauro Wanderley. João Pessoa, PB, Brazil. | en_US |
| Affilliation | Universidade de Fortaleza. Hospital Geral de Fortaleza. Fortaleza, CE, Brazil. | en_US |
| Affilliation | Universidade de Fortaleza. Hospital Geral de Fortaleza. Fortaleza, CE, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento do Sistema Locomotor. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Juiz de Fora. Faculdade de Medicina. Juiz de Fora, MG, Brazil. | en_US |
| Affilliation | Estado do Espírito Santo. Secretaria de Saúde. Centro de Referências para Imunobiológicos Especiais. Vitória, ES, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Escola de Medicina. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre, RS, Brazil/Health Research and Innovation Science Centre. Klaipeda University. Klaipeda, Lithuania. | en_US |
| Affilliation | Universidade Federal Fluminense. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Escola de Medicina. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Universidade Federal de Juiz de Fora. Faculdade de Medicina. Juiz de Fora, MG, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil. | en_US |
| Affilliation | Autores com diversas filiações | en_US |
| Subject | COVID-19 | en_US |
| Subject | Health disparities | en_US |
| Subject | Rheumatic diseases | en_US |
| Subject | Vaccination of immune compromised patients | en_US |
