| Author | Opretzka, Luiza Carolina França | |
| Author | Pinto, Cláudio Damasceno | |
| Author | Santos, Jânio Rodrigo de Jesus | |
| Author | Lima, Alyne Almeida de | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Villarreal, Cristiane Flora | |
| Access date | 2024-12-09T19:43:41Z | |
| Available date | 2024-12-09T19:43:41Z | |
| Document date | 2024 | |
| Citation | OPRETZKA, Luiza Carolina França et al. Mesenchymal stem cell‑derived cell‑free technologies: a patent landscape. Biotechnology Letters, v. 46, n. 5, p. 1-18, 2024. | en_US |
| ISSN | 1573-6776 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67496 | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | Springer | en_US |
| Rights | restricted access | |
| Title | Mesenchymal stem cell‑derived cell‑free technologies: a patent landscape | en_US |
| Type | Article | |
| DOI | 10.1007/s10529-024-03506-y | |
| Abstract | Mesenchymal stem/stromal cells (MSC) play a pivotal role in regenerative therapies. Recent studies show that factors secreted by MSC can replicate their biological activity, driving the emergence of cell-free therapy, likely to surpass stem cell therapy. Patents are an objective measure of R&D and innovation activities, and patent mapping allows us to verify the state of the art and technology, anticipate trends, and identify emerging lines of research. This review performed a search on Derwent World Patents Index™ and retrieved 269 patent families related to the MSC-derived cell-free products. Analysis reveals an exponential increase in patents from the mid-2010s, primarily focusing on exosomes. The patent's contents offer a great diversity of applications and associated technologies by using the products as medicinal agents or drug delivery systems. Nevertheless, numerous application branches remain unexplored, suggesting vast potential for cell-free technologies alone or combined with other approaches. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, Bahia, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, Bahia, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, Bahia, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, Bahia, Brasil / Instituto de Sistemas Avançados em Saúde. SENAI CIMATEC. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Subject | Cell-free therapy | en_US |
| Subject | Exosomes | en_US |
| Subject | Mesenchymal stem/stromal cells | en_US |
| Subject | Patent mapping | en_US |
| Subject | Secretome | en_US |
| DeCS | Exossomos | en_US |
| DeCS | Células-tronco mesenquimais | en_US |
| DeCS | Secretoma | en_US |
| Embargo date | 2027 | |
