| Author | Tesch, Ricardo de Souza | |
| Author | Takamori, Esther Rieko | |
| Author | Menezes, Karla | |
| Author | Carias, Rosana Bizon Vieira | |
| Author | Rebelatto, Carmen Lucia Kuniyoshi | |
| Author | Senegaglia, Alexandra Cristina | |
| Author | Daga, Debora Regina | |
| Author | Fracaro, Leticia | |
| Author | Robert, Anny Waloski | |
| Author | Pinheiro, Carlos Bruno Reis | |
| Author | Aguiar, Marcelo de Freitas | |
| Author | Blanco, Pablo Javier | |
| Author | Zilves, Eduardo Guerreiro | |
| Author | Brofman, Paulo Roberto Slud | |
| Author | Borojevic, Radovan | |
| Access date | 2024-12-12T11:37:12Z | |
| Available date | 2024-12-12T11:37:12Z | |
| Document date | 2024 | |
| Citation | TESCH, R. S. et al. Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial. Stem Cells Translational Medicine, v. 13, n. 7, p. 593–605, 2024. | en_US |
| ISSN | 2157-6580 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67541 | |
| Sponsorship | This study has received the major support of the Octacilio Gualberto Foundation (FOG), and it has received a grant from the Rio de Janeiro State Research Support Foundation (FAPERJ), No. E-26/ 111.301/2013. | en_US |
| Language | eng | en_US |
| Publisher | OXFORD | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Terapia celular | en_US |
| Subject in Portuguese | Células progenitoras | en_US |
| Subject in Portuguese | Translacional clínico | en_US |
| Title | Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial | en_US |
| Type | Article | en_US |
| DOI | 10.1093/stcltm/szae026 | |
| Abstract | Condylar resorption is an aggressive and disability form of temporomandibular joint (TMJ) degenerative disease, usually non-respondent to conservative or minimally invasive therapies and often leading to surgical intervention and prostheses implantation. This condition is also one of the most dreaded postoperative complications of orthognathic surgery, with severe cartilage erosion and loss of subchondral bone volume and mineral density, associated with a painful or not inflammatory processes. Because regenerative medicine has emerged as an alternative for orthopedic cases with advanced degenerative joint disease, we conducted a phase I/IIa clinical trial (U1111-1194-6997) to evaluate the safety and efficacy of autologous nasal septal chondroprogenitor cells. Ten participants underwent biopsy of the nasal septum cartilage during their orthognathic surgery. The harvested cells were cultured in vitro and analyzed for viability, presence of phenotype markers for mesenchymal stem and/or chondroprogenitor cells, and the potential to differentiate into chondrocytes, adipocytes, and osteoblasts. After the intra-articular injection of the cell therapy, clinical follow-up was performed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and computed tomography (CT) images. No serious adverse events related to the cell therapy injection were observed during the 12-month follow-up period. It was found that autologous chondroprogenitors reduced arthralgia, promoted stabilization of mandibular function and condylar volume, and regeneration of condylar tissues. This study demonstrates that chondroprogenitor cells from the nasal septum may be a promise strategy for the treatment of temporomandibular degenerative joint disease that do not respond to other conservative therapies. | en_US |
| Affilliation | Petrópolis Medical School. Regenerative Medicine Laboratory. Petrópolis, RJ, Brasil. | en_US |
| Affilliation | Petrópolis Medical School. Regenerative Medicine Laboratory. Petrópolis, RJ, Brasil. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Petrópolis Medical School. Regenerative Medicine Laboratory. Petrópolis, RJ, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica do Paraná. School of Medicine and Life Sciences. Core for Cell Technology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica do Paraná. School of Medicine and Life Sciences. Core for Cell Technology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica do Paraná. School of Medicine and Life Sciences. Core for Cell Technology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica do Paraná. School of Medicine and Life Sciences. Core for Cell Technology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil. | en_US |
| Affilliation | State University of Rio de Janeiro. Postgraduate Program in Exercise and Sport Sciences. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fluminense Federal University. Health Institute of Nova Friburgo. School of Dentistry. Department of Specific Formation. Nova Friburgo, RJ, Brasil. | en_US |
| Affilliation | National Laboratory for Scientific Computing. Department of Mathematical and Computational Models. Petrópolis, RJ, Brasil. | en_US |
| Affilliation | National Laboratory for Scientific Computing. Department of Mathematical and Computational Models. Petrópolis, RJ, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica do Paraná. School of Medicine and Life Sciences. Core for Cell Technology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Petrópolis Medical School. Regenerative Medicine Laboratory. Petrópolis, RJ, Brasil. | en_US |
| Subject | Cellular therapy | en_US |
| Subject | Progenitor cells | en_US |
| Subject | Skeleton | en_US |
| Subject | Clinical translational | en_US |
| DeCS | Terapia celular | en_US |
| DeCS | Estudo clínico | en_US |
| DeCS | Articulação Temporomandibular | en_US |
| DeCS | Doença degenerativa | en_US |
