Author | Morais, Cristiane Guimarães | |
Author | Soares, Irene da Silva | |
Author | Carvalho, Luzia Helena de | |
Author | Fontes, Cor Jesus Fernandes | |
Author | Krettli, Antoniana Ursine | |
Author | Braga, Érika Martins | |
Access date | 2013-08-06T12:16:07Z | |
Available date | 2013-08-06T12:16:07Z | |
Document date | 2005 | |
Citation | MORAIS, Cristiane G et al. IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil. Parasitol Res. 2005 Apr;95(6):420-6 | pt_BR |
ISSN | 0932-0113 | |
URI | https://www.arca.fiocruz.br/handle/icict/6756 | |
Language | eng | pt_BR |
Publisher | Springer | pt_BR |
Rights | restricted access | pt_BR |
Title | IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil | pt_BR |
Type | Article | pt_BR |
Abstract | Subclasses of antibodies to the C-terminal 19 kDa fragment of the Plasmodium vivax merozoite surface protein 1 (PvMSP-1(19)) were assessed among subjects with distinct degrees of malaria exposure in the Brazilian endemic area. The PvMSP-1(19) specific IgG1and IgG3 levels were low among subjects with long-term exposure (approximately 19 years) when compared to subjects less and sporadically exposed (<1 year). No statistically difference was observed in IgG subclass distribution of antibodies from symptomatic Plasmodium-infected patients, asymptomatic parasite carriers and non-infected subjects living in a same mesoendemic area. Subjects briefly exposed to a P. vivax outbreak living in a rural community outside the endemic area were also evaluated to measure the persistence of specific antibodies. IgG anti-PvMSP-1(19) antibodies persisted in 40% of the subjects who had had malarial symptoms 8 months before and decreased after 7 years (28%). Specific IgG1 were the predominant isotype. Our study emphasizes the highly immunogenicity of the PvMSP-1(19) and points toward its possible use as a potential malaria vaccine. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Departamento de Analises Clínicas e Toxicológicas. Universidade de São Paulo. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso. Departamento de Clínica Médica. Cuiabá, MT, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Antibodies, Protozoan/blood | pt_BR |
Subject | Immunoglobulin G/blood | pt_BR |
Subject | Malaria, Falciparum/epidemiology | pt_BR |
Subject | Merozoite Surface Protein 1/genetics | pt_BR |