| Author | Moreira, Laís de Souza Gouveia | |
| Author | Teixeira, Karla Thaís Resende | |
| Author | Cardozo, Ludmila F. M. F. | |
| Author | Alvarenga, Livia | |
| Author | Regis, Bruna | |
| Author | Brito, Jessyca Sousa de | |
| Author | Leal, Viviane de Oliveira | |
| Author | Borges, Natalia Alvarenga | |
| Author | Brum, Isabela de Souza da Costa | |
| Author | Carraro-Eduardo, José Carlos | |
| Author | Borini, Giovanna B. | |
| Author | Berretta, Andresa A. | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Mafra, Denise | |
| Access date | 2024-12-23T02:00:00Z | |
| Available date | 2024-12-23T02:00:00Z | |
| Document date | 2024 | |
| Citation | MOREIRA, Laís de Souza Gouveia et al. Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial. Journal of Nutrition and Metabolism, v. 2024, p. 1-11, May 2024. | en_US |
| ISSN | 2090-0724 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67752 | |
| Sponsorship | Financial support as provided by the National Council for Scientifc and Technological Development (Conselho Nacional de Desenvolvimento Cient´ıfco e Tecnologico- CNPq), the Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de N´ıvel Superior - CAPES), and the Research
Support Foundation of Rio de Janeiro (Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro -FAPERJ). | en_US |
| Language | eng | en_US |
| Publisher | Hindawi | en_US |
| Rights | open access | en_US |
| Title | Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial | en_US |
| Type | Article | en_US |
| DOI | 10.1155/2024/9590066 | |
| Abstract | Background: Growing evidence suggests that bioactive compounds in berry fruits may mitigate inflammation in patients with chronic kidney disease (CKD). Objectives: To evaluate cranberry (Vaccinium macrocarpon) supplementation effects on modulation of transcription factors involved in inflammation and oxidative stress in nondialysis (stages 3 and 4) patients with CKD. Design/Participants. A randomized, double-blind, placebo-controlled study was performed with 30 patients to receive capsules containing cranberry extract (1000 mg/day) or placebo (1000 mg/day of corn starch) for two months. Measurements. The mRNA expression of nuclear factor-erythroid 2-related factor-2 (Nrf2) and nuclear factor-kB (NF-kB) was evaluated in peripheral blood mononuclear cells (PBMCs) by quantitative real-time polymerase chain reaction. Thiobarbituric acid reactive substances (TBARS) were measured in the plasma to assess oxidative stress. Interleukin-6 (IL-6) plasma levels were assessed by enzyme-linked immunosorbent assay and C-reactive protein (CRP) by immunoturbidimetric method. Results: Twenty-five patients completed the study: 12 in the cranberry group (56.7 ± 7.5 years and body mass index (BMI) of 29.6 ± 5.5 kg/m2) and 13 in the placebo group (58.8 ± 5.1 years and BMI 29.8 ± 5.4 kg/m2). There were no differences in NF-kB or Nrf2 mRNA expressions (p = 0.99 and p = 0.89) or TBARS, CRP, and IL-6 plasma levels after cranberry supplementation. Conclusions: The cranberry extract administration (1000 mg/day) did not affect Nrf2 and NF-kB mRNA expression, oxidative stress, or inflammatory markers levels in nondialysis CKD patients. This trial is registered with NCT04377919. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Graduate Program in Biological Sciences - Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Graduate Program in Biological Sciences - Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Rio de Janeiro State University. Pedro Ernesto University Hospital. Nutrition Division. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Rio de Janeiro State University. Institute of Nutrition. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Faculty of Medicine. Niterói, RJ, Brazil. | en_US |
| Affilliation | Research, Development & Innovation Department. Apis Flora Industrial e Comercial Ltda. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Research, Development & Innovation Department. Apis Flora Industrial e Comercial Ltda. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Graduate Program in Biological Sciences - Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Chronic Kidney Disease (Stages 3-4) | en_US |
| Subject | Vaccinium macrocarpon | en_US |
| Subject | mRNA | en_US |
| Subject | Nrf2 | en_US |
| Subject | NF-kB | en_US |
| e-ISSN | 2090-0732 | |
