| Author | Taufer, Nathali Parise | |
| Author | Santos-Souza, Camila | |
| Author | Larentis, Lucas Trentin | |
| Author | Santos, Claudia Nunes Duarte | |
| Author | Creuzet, Sophie Emmanuelle | |
| Author | Garcez, Ricardo Castilho | |
| Access date | 2024-12-25T13:36:00Z | |
| Available date | 2024-12-25T13:36:00Z | |
| Document date | 2024 | |
| Citation | TAUFER, Nathali Parise et al. Integrative analysis of molecular pathways and morphological anomalies associated with congenital Zika syndrome. Journal of the Neurological Sciences, v. 465, n. 123190, p. 1-14, 2024. | en_US |
| ISSN | 0022-510X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67779 | |
| Description | Supplementary data to this article can be found online at https://doi.org/10.1016/j.jns.2024.123190. | en_US |
| Sponsorship | This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001; NPT received scholarships from CAPES (grant numbers 88887.489649/2020-00 and 88887.843573/2023-00); CSS received scholarship from CAPES (grant number 88887.808454/2023-00). This work was supported by Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) through a scholarship to LTL (grant notice number 48/2021), and by parliamentary amendments/Ministry of Science, Technology, and Innovation (numbers 71260014/2020 and 41850003/2021). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Subject in Portuguese | Vírus Zika | en_US |
| Subject in Portuguese | Microcefalia | en_US |
| Subject in Portuguese | Desenvolvimento ósseo | en_US |
| Subject in Portuguese | Análise de cluster | en_US |
| Subject in Portuguese | Mapa de interação de proteínas | en_US |
| Title | Integrative analysis of molecular pathways and morphological anomalies associated with congenital Zika syndrome | en_US |
| Type | Article | |
| DOI | 10.1016/j.jns.2024.123190 | |
| Abstract | Congenital Zika syndrome (CZS) comprises a set of clinical manifestations that can be presented by neonates born to mothers infected by the Zika virus (ZIKV). CZS-associated phenotypes include neurological, skeletal, and systemic alterations and long-term developmental sequelae. One of the most frequently reported clinical conditions is microcephaly characterized by a reduction in head circumference and cognitive complications. Nevertheless, the associations among the diverse signaling pathways underlying CZS phenotypes remain to be elucidated. To shed light on CZS, we have extensively reviewed the morphological anomalies resulting from ZIKV infection, as well as genes and proteins of interest obtained from the published literature. With this list of genes or proteins, we performed computational analyses to explore the cellular processes, molecular mechanisms, and molecular pathways related to ZIKV infection. Therefore, in this review, we comprehensively describe the morphological abnormalities caused by congenital ZIKV infection and, through the analysis noted above, propose common molecular pathways altered by ZIKV that could explain both central nervous system and craniofacial skeletal alterations. | en_US |
| Affilliation | Universidade Federal de Santa Catarina. Graduate Program in Cell and Developmental Biology. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Department of Cell Biology, Embryology, and Genetics. Laboratório de Células-Tronco e Regeneração Tecidual. Florianópolis, SC, Brasil. | en_US |
| Affilliation | Universidade Federal de Santa Catarina. Graduate Program in Cell and Developmental Biology. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Department of Cell Biology, Embryology, and Genetics. Laboratório de Células-Tronco e Regeneração Tecidual. Florianópolis, SC, Brasil. | en_US |
| Affilliation | Universidade Federal de Santa Catarina. Graduate Program in Cell and Developmental Biology. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Department of Cell Biology, Embryology, and Genetics. Laboratório de Células-Tronco e Regeneração Tecidual. Florianópolis, SC, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Paris-Saclay University. Institut des Neurosciences Paris-Saclay (NeuroPSI). Centre National de la Recherche Scientifique. Saclay, France. | en_US |
| Affilliation | Universidade Federal de Santa Catarina. Graduate Program in Cell and Developmental Biology. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Department of Cell Biology, Embryology, and Genetics. Laboratório de Células-Tronco e Regeneração Tecidual. Florianópolis, SC, Brasil. | en_US |
| Subject | Zika virus | en_US |
| Subject | Microcephaly | en_US |
| Subject | Bone development | en_US |
| Subject | Gene networks | en_US |
| Subject | Cluster analysis | en_US |
| Subject | Protein interaction maps | en_US |
| DeCS | Microcefalia | en_US |
| DeCS | Zika virus | en_US |
| DeCS | Desenvolvimento Ósseo | en_US |
| Embargo date | 2034 | |
