| Author | Pedroso, Rodrigo Balsinha | |
| Author | Torres, Lícia | |
| Author | Ventura, Lucas Araújo | |
| Author | Camatta, Giovanna Caliman | |
| Author | Mota, Catarina | |
| Author | Mendes, Ana Catarina | |
| Author | Ribeiro, Filipa | |
| Author | Guimarães, Henrique Cerqueira | |
| Author | Barbuto, Rafael Calvão | |
| Author | Caixeta, Felipe | |
| Author | Nascimento, Leandro Souza | |
| Author | Oliveira, Mariana Almeida | |
| Author | Martins, Vinícius Dantas | |
| Author | Silveira-Nunes, Gabriela | |
| Author | Tupinambás, Unaí | |
| Author | Carvalho, Andrea Teixeira | |
| Author | Graça, Luis | |
| Author | Faria, Ana Maria Caetano | |
| Access date | 2024-12-27T19:21:23Z | |
| Available date | 2024-12-27T19:21:23Z | |
| Document date | 2024 | |
| Citation | PEDROSO, Rodrigo Balsinha et al. Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection. J Leukoc Biol, v. 116, n. 6, p. 1385-1397, 2024 | en_US |
| ISSN | 0741-5400 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67820 | |
| Language | eng | en_US |
| Publisher | Oxford University Press | en_US |
| Rights | restricted access | |
| Subject in Portuguese | COVID-19 | en_US |
| Title | Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | en_US |
| Type | Article | |
| DOI | 10.1093/jleuko/qiae180 | |
| Abstract | Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with severe COVID-19 have an accumulation of senescent T cells, suggesting that immunosenescence may be aggravated by SARS-CoV-2 infection. The present work was designed to examine whether these immunosenescence changes are characteristic of COVID-19 and whether it is dependent on disease severity using cross-sectional and longitudinal studies. Our cross-sectional data show that COVID-19, but not other respiratory infections, rapidly increased cellular senescence and exhaustion in CD4 and CD8 T cells during early infection. In addition, longitudinal analyses with patients from Brasil. and Portugal provided evidence of increased frequencies of senescent and exhausted T cells over a 7-d period in patients with mild/moderate and severe COVID-19. Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection. | en_US |
| Affilliation | Universidade de Lisboa. Faculdade de Medicina. Instituto de Medicina Molecular. Lisboa, Portugal. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade de Lisboa. Faculdade de Medicina. Instituto de Medicina Molecular. Lisboa, Portugal. | en_US |
| Affilliation | Universidade de Lisboa. Faculdade de Medicina. Instituto de Medicina Molecular. Lisboa, Portugal. | en_US |
| Affilliation | Universidade de Lisboa. Faculdade de Medicina. Instituto de Medicina Molecular. Lisboa, Portugal. | en_US |
| Affilliation | Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil . | en_US |
| Affilliation | Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Juiz de Fora. Departamento de Medicina. Governador Valadares, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade de Lisboa. Faculdade de Medicina. Instituto de Medicina Molecular. Lisboa, Portugal. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | T-cell exhaustion | en_US |
| Subject | T-cell senescence | en_US |
| Subject | Immunosenescence | en_US |
| Subject | Inflammaging | en_US |
| Subject | Inflammatory cytokines | en_US |
| Embargo date | 3100-12-31 | |
