| Author | Quirino, Ângela | |
| Author | Marascio, Nadia | |
| Author | Branda, Francesco | |
| Author | Ciccozzi, Alessandra | |
| Author | Romano, Chiara | |
| Author | Locci, Chiara | |
| Author | Azzena, Ilenia | |
| Author | Pascale, Noemi | |
| Author | Pavia, Grazia | |
| Author | Matera, Giovanni | |
| Author | Casu, Marco | |
| Author | Sanna, Daria | |
| Author | Giovanetti, Marta | |
| Author | Ceccarelli, Giancarlo | |
| Author | Loro, Pierfrancesco Alaimo di | |
| Author | Ciccozzi, Massimo | |
| Author | Scarpa, Fabio | |
| Author | Maruotti, Antonello | |
| Access date | 2025-01-06T16:46:21Z | |
| Available date | 2025-01-06T16:46:21Z | |
| Document date | 2024 | |
| Citation | QUIRINO, Ângela et al. Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies. Pathogens, v. 13, n. 9, 766, 2024. | en_US |
| ISSN | 2076-0817 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67873 | |
| Language | eng | en_US |
| Publisher | MPDI | en_US |
| Rights | open access | en_US |
| Title | Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies. | en_US |
| Type | Article | |
| DOI | 10.3390/pathogens13090766. | |
| Abstract | Viral hepatitis is a major cause of liver illness worldwide. Despite advances in the understanding of these infections, the pathogenesis of hepatitis remains a complex process driven by intricate interactions between hepatitis viruses and host cells at the molecular level. This paper will examine in detail the dynamics of these host-pathogen interactions, highlighting the key mechanisms that regulate virus entry into the hepatocyte, their replication, evasion of immune responses, and induction of hepatocellular damage. The unique strategies employed by different hepatitis viruses, such as hepatitis B, C, D, and E viruses, to exploit metabolic and cell signaling pathways to their advantage will be discussed. At the same time, the innate and adaptive immune responses put in place by the host to counter viral infection will be analyzed. Special attention will be paid to genetic, epigenetic, and environmental factors that modulate individual susceptibility to different forms of viral hepatitis. In addition, this work will highlight the latest findings on the mechanisms of viral persistence leading to the chronic hepatitis state and the potential implications for the development of new therapeutic strategies. Fully understanding the complex host-pathogen interactions in viral hepatitis is crucial to identifying new therapeutic targets, developing more effective approaches for treatment, and shedding light on the mechanisms underlying progression to more advanced stages of liver damage. | en_US |
| Affilliation | "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy. | en_US |
| Affilliation | "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy. | en_US |
| Affilliation | Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | en_US |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. | en_US |
| Affilliation | Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | en_US |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. / University of Sassari. Department of Veterinary Medicine. Sassari, Italy. | en_US |
| Affilliation | University of Sassari. Department of Veterinary Medicine. Sassari, Italy | en_US |
| Affilliation | University of Sassari. Department of Veterinary Medicine. Sassari, Italy. / University of Sassari. Department of Chemical Physical Mathematical and Natural Sciences. Sassari, Italy. | en_US |
| Affilliation | "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy. | en_US |
| Affilliation | "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy. | en_US |
| Affilliation | University of Sassari. Department of Veterinary Medicine. Sassari, Italy. | en_US |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. | en_US |
| Affilliation | Università Campus Bio-Medico di Roma. Department of Sciences and Technologies for Sustainable Development and One Health. Rome, Italy / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / Climate Amplified Diseases and Epidemics. Brasilia, DF, Brasil. | en_US |
| Affilliation | Sapienza University of Rome. University Hospital Policlinico Umberto I. Department of Public Health and Infectious Diseases. Rome, Italy. | en_US |
| Affilliation | Libera Università Maria Ss Assunta. Department GEPLI. Rome, Italy. | en_US |
| Affilliation | Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | en_US |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. | en_US |
| Affilliation | Libera Università Maria Ss Assunta. Department GEPLI. Rome, Italy. | en_US |
| Subject | Host–pathogen interactions | en_US |
| Subject | Immune evasion mechanisms | en_US |
| Subject | Therapeutic strategies | en_US |
| Subject | Viral hepatitis | en_US |
| Subject | Viral persistence | en_US |
