| Author | Silva, Jéssica Cavaleiro da | |
| Author | Caetano, Amanda Rodrigues | |
| Author | Mendonça, Ana Carolina da Fonseca | |
| Author | Scalioni, Letícia de Paula | |
| Author | Portilho, Moyra Machado | |
| Author | Bezerra, Cristianne Sousa | |
| Author | Marques, Vanessa Alves | |
| Author | Cruz, Juliana Custódio Miguel | |
| Author | Rodrigues, Káris Maria de Pinho | |
| Author | Ivantes, Cláudia Alexandra Pontes | |
| Author | Lewis Ximenez, Lia Laura | |
| Author | Villar, Livia Melo | |
| Access date | 2025-01-07T16:40:13Z | |
| Available date | 2025-01-07T16:40:13Z | |
| Document date | 2024 | |
| Citation | SILVA, Jéssica Cavaleiro da et al. Lack of association between vitamin D genetic polymorphism and virological characteristics of hepatitis B infection. The Journal of Applied Laboratory Medicine, p. 1-12, 31 Dec. 2024. | |
| ISSN | 2475-7241 | |
| URI | https://www.arca.fiocruz.br/handle/icict/67928 | |
| Description | Produção científica do Laboratório de Hepatites Virais. | pt_BR |
| Sponsorship | This research was funded by Oswaldo Cruz IOC/Fiocruz/Ministry of Health, Brazil; and the Brazilian national funding agencies (Conselho Nacional de Desenvolvimento Científico e Tecnológico of Brazil—CNPq under the financial code 409231/2023-1, Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro—FAPERJ under the financial code SEI 260003/001152/2023, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior of Brasil—CAPES, and FIOCRUZ under the financial code IOC-008-FIO-22-2-44-30). | |
| Language | eng | en_US |
| Publisher | Oxford University Press | |
| Rights | restricted access | |
| Title | Lack of association between vitamin D genetic polymorphism and virological characteristics of hepatitis B infection | en_US |
| Type | Article | |
| DOI | 10.1093/jalm/jfae151 | |
| Abstract | Background: Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods: 126 CHB patients were enrolled in the current study and clinical, laboratory, and 25-hydroxyvitamin D [25(OD)D] level data were obtained. Four VDR (rs7975232, rs1544410, rs10735810, rs731236) and 2 vitamin D-binding protein/carrier globulin (GC) polymorphisms (rs4588 and rs7041) were determined using TaqMan assays and nucleotide sequencing. Association studies were conducted among viral infection parameters and the patient's genetic variants. Results: Most patients were male (52.38%) with a mean age of 44.28 (±14.24) years, self-identified as White (32.54%), and exhibited vitamin D insufficiency status (42.06%). The hepatitis B virus (HBV) genotype A was predominant (50%) and 62.7% of the patients had detectable HBV DNA levels ≤log₁₀ 3 IU/mL. A significant association was observed between HBV genotype A with ApaI and FokI single nucleotide polymorphisms. However, no statistical association between VDR polymorphisms and viral load, viral polymerase mutations, or vitamin D status was found. Vitamin D concentration did not correlate to HBV viral load. Conclusions: Most HBV-infected individuals presented vitamin D insufficiency, and VDR polymorphism was not associated with virological characteristics except with HBV genotype A, demonstrating that some human genetic signatures are related to HBV genotype distribution. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia do Ceará. Fortaleza, CE, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Prefeitura Municipal de Curitiba. Centro de Orientação e Aconselhamento. Curitiba, PR, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | |
| Subject | Vitamin D receptor (VDR) polymorphisms | en_US |
| Subject | Hepatitis B virus | en_US |
| Subject | Genetic variants | en_US |
| Subject | Vitamin D deficiency | en_US |
| e-ISSN | 2475-7241 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
