| Author | Alves, Victor Menezes Tunholi | |
| Author | Amaral, Ludimila Santos | |
| Author | Sperandio, Natânia do Carmo | |
| Author | Altoé, Lorena Souza Castro | |
| Author | Alves, Vinícius Menezes Tunholi | |
| Author | Garcia, Juberlan Silva | |
| Author | Mota, Ester Maria | |
| Author | Chambarelli, Melissa Carvalho Machado do Couto | |
| Author | Monteiro, Caio Márcio de Oliveira | |
| Author | Martins, Isabella Vilhena Freire | |
| Access date | 2025-01-28T17:26:45Z | |
| Available date | 2025-01-28T17:26:45Z | |
| Document date | 2024 | |
| Citation | ALVES, Victor Menezes Tunholi et al. Metabolic disruptions in biomphalaria glabrata induced by heterorhabditis bacteriophora HP88: implications for entomopathogenic nematodes in biological control. Experimental Parasitology, v. 263-264, p. 1-7, Aug./Sept. 2024. | |
| ISSN | 0014-4894 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68291 | |
| Description | Produção científica do Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. | pt_BR |
| Description | Produção científica do Laboratório de Patologia (vigente até jan/2023). | pt_BR |
| Sponsorship | This study received funding from the Espírito Santo State Foundation for Research Support (FAPES) and the National Council for Scientific and Technological Development (CNPq) number 150441/2022–3. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | Metabolic disruptions in biomphalaria glabrata induced by heterorhabditis bacteriophora HP88: implications for entomopathogenic nematodes in biological control | en_US |
| Type | Article | |
| DOI | 10.1016/j.exppara.2024.108804 | |
| Abstract | Research on the use of entomopathogenic nematodes (EPNs) as a potential tool for the biological control of invertebrates has been growing in recent years, including studies involving snails with One Health importance. In this study, the effect of exposure time (24 or 48 h) of Heterorhabditis bacteriophora HP88 on the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the concentration of total proteins, uric acid, and urea in the hemolymph of Biomphalaria glabrata, were investigated. The concentrations of these metabolic markers were measured weekly until the end of the third week after exposure. Along with a significant reduction in total protein levels, a significant increase (p < 0.01) in uric acid and urea contents in the hemolymph of B. glabrata exposed to H. bacteriophora was observed. The accumulation of urea in these mollusks could lead to deleterious effects due to its high toxicity, inducing significant cell damage. Variations in transaminase activities were also observed, with snails exposed to EPNs showing significantly higher values (p < 0.01) than individuals in the control group, both for ALT and AST. These results indicate that experimental exposure to infective juveniles of H. bacteriophora causes significant alterations in the metabolic pattern of B. glabrata, compromising the maintenance of its homeostasis. Finally, exposure for 48 h caused more damage to the planorbid in question compared to snails exposed for 24 h, suggesting that the exposure time may influence the intensity of the host's response. | en_US |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Departamento de Microbiologia, Imunologia, Parasitologia e Patologia. Goiânia, GO, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências Agrárias e Engenharias. Departamento de Medicina Veterinária. Alegre, ES, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências Agrárias e Engenharias. Departamento de Medicina Veterinária. Alegre, ES, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências Humanas e Naturais. Departamento de Ciências Biológicas. Núcleo de Genética Humana e Molecular. Grupo de Biologia Computacional e de Sistemas. Vitória, ES, Brasil. | |
| Affilliation | Universidade Estácio de Sá. Programa Pesquisa Produtividade. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Medicina Veterinária. Departamento de Parasitologia Animal. Seropédica, RJ, Brasil. | |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Departamento de Microbiologia, Imunologia, Parasitologia e Patologia. Goiânia, GO, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências Agrárias e Engenharias. Departamento de Medicina Veterinária. Alegre, ES, Brasil. | |
| Subject | Entomopathogenic nematodes (EPNs) | en_US |
| Subject | Schistosoma mansoni | en_US |
| Subject | Parasite-host relationship | en_US |
| Subject | Biomphalaria glabrata | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 15 Vida terrestre | |
