| Author | Christoff, Raissa Rilo | |
| Author | Liesner, Isabelle Lemos | |
| Author | Leopoldino, Daniel Gavino | |
| Author | Andrade, Bruna de Oliveira | |
| Author | Campos, Beatriz Oliveira de | |
| Author | Mael, Isabella Salgado | |
| Author | Lemos, Felipe Simões | |
| Author | Poian, Andrea Thompson da | |
| Author | Miranda, Iranaia Assunção | |
| Author | Figueiredo, Cláudia Pinto | |
| Author | Clarke, Julia Helena Rosauro | |
| Access date | 2025-01-29T12:13:19Z | |
| Available date | 2025-01-29T12:13:19Z | |
| Document date | 2024 | |
| Citation | CHRISTOFF, Raissa Rilo et al. TNF-α blockage prevents late neurological consequences of zika virus infection in mice. Behavioural Brain Research, v. 471, p. 1-7, 5 Aug. 2024. | |
| ISSN | 0166-4328 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68298 | |
| Sponsorship | This work was funded by Fundação de Amparo à Pesquisa no Estado do Rio de Janeiro (Grant number 26/202.740/2019) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (Grant Number 305511/2018-1). Raissa Rilo Christoff, Isabelle Lemos Liesner, Daniel Gavino Leopoldino and Felipe Simões Lemos received fellowships from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | TNF-α blockage prevents late neurological consequences of zika virus infection in mice | en_US |
| Type | Article | |
| DOI | 10.1016/j.bbr.2024.115114 | |
| Abstract | Zika virus (ZIKV) is a neurotropic Orthoflavivirus that causes a myriad of neurological manifestations in newborns exposed in uterus. Despite the devastating consequences of ZIKV on the developing brain, strategies to prevent or treat the consequences of viral infection are not yet available. We previously showed that short-term treatment with the TNF-α neutralizing monoclonal antibody. Infliximab could prevent seizures at acute and chronic stages of ZIKV infection, but had no impact on long-term cognitive and motor dysfunction. Due to the central role of inflammation in ZIKV-neuropathology, we hypothesized that prolonged treatment with the anti-TNF-α monoclonal antibody Infliximab could provide complete rescue of long-term behavioral deficits associated with neonatal ZIKV infection in mice. Here, neonatal (post-natal day 3) Swiss mice were submitted to subcutaneous (s.c.) injection of 10⁶ PFU of ZIKV or mock medium and were then treated with Infliximab (20 μg/day) or sterile saline intraperitoneally (i.p.), for 40 days starting on the day of infection, and behavioral assessment started at 60 days post-infection (dpi). Infliximab prevented ZIKV-induced cognitive and motor impairments in mice. In addition, microgliosis and cell death found in mice following ZIKV infection were partially reversed by TNF-α blockage. Altogether, these results suggest that TNF-α-mediated inflammation is central for late ZIKV-induced behavioral deficits and cell death and strategies targeting this cytokine may be promising approaches to treat subjects exposed to the virus during development. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | |
| Subject | Congenital zika syndrome | en_US |
| Subject | Microcephaly | en_US |
| Subject | TNF-α | en_US |
| Subject | Neuroinflammation | en_US |
| Subject | Infliximab | en_US |
| Subject | Motor impairment, seizures | en_US |
| e-ISSN | 1872-7549 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
