| Author | Nóbrega, Ana Helena Larangeira | |
| Author | Pimentel, Rafael Sampaio | |
| Author | Prado, Ana Paula Soares do | |
| Author | Garcia, Jenifer Roberta Ferreira | |
| Author | Frozza, Rudimar Luiz | |
| Author | Bernardi, Andressa | |
| Access date | 2025-02-04T12:16:06Z | |
| Available date | 2025-02-04T12:16:06Z | |
| Document date | 2024 | |
| Citation | NÓBREGA, Ana Helena Larangeira et al. Neuroinflammation in glioblastoma: the role of the microenvironment in tumour progression. Current Cancer Drug Targets, v. 24, n. 6, p. 579-594, 17 Jan. 2024. | |
| ISSN | 1568-0096 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68398 | |
| Description | Produção científica do Laboratório de Inflamação. | pt_BR |
| Description | Produção científica do Laboratório de Pesquisa sobre o Timo. | pt_BR |
| Sponsorship | This study was supported by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (Grants no's. E-26/200.169/2023. E-26/201.419/2021, E-26/202.807/2019), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The Project is also supported by Rede Rio de Inovação em Nanossistemas para a Saúde - NanoSAÚDE/FAPERJ (Grant # E-26/010.000983/2019). Andressa Bernardi is the recipient of Productivity Grants in CNPq. | |
| Language | eng | en_US |
| Publisher | Bentham Science Publishers | |
| Rights | restricted access | |
| Title | Neuroinflammation in glioblastoma: the role of the microenvironment in tumour progression | en_US |
| Type | Article | |
| DOI | 10.2174/0115680096265849231031101449 | |
| Abstract | Glioblastoma (GBM) stands as the most aggressive and lethal among the main types of primary brain tumors. It exhibits malignant growth, infiltrating the brain tissue, and displaying resistance toward treatment. GBM is a complex disease characterized by high degrees of heterogeneity. During tumour growth, microglia and astrocytes, among other cells, infiltrate the tumour microenvironment and contribute extensively to gliomagenesis. Tumour-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, are the most numerous nonneoplastic populations in the tumour microenvironment in GBM. The complex heterogeneous nature of GBM cells is facilitated by the local inflammatory tumour microenvironment, which mostly induces tumour aggressiveness and drug resistance. The immunosuppressive tumour microenvironment of GBM provides multiple pathways for tumour immune evasion, contributing to tumour progression. Additionally, TAMs and astrocytes can contribute to tumour progression through the release of cytokines and activation of signalling pathways. In this review, we summarize the role of the microenvironment in GBM progression, focusing on neuroinflammation. These recent advancements in research of the microenvironment hold the potential to offer a promising approach to the treatment of GBM in the coming times. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | |
| Subject | Glioblastoma | en_US |
| Subject | Tumour microenvironment | en_US |
| Subject | Neuroinflammation | en_US |
| Subject | TAMs | en_US |
| Subject | Microglia | en_US |
| Subject | Astrocytes | en_US |
| e-ISSN | 1873-5576 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
