| Author | Castanha, P. M. S. | |
| Author | Montarroyos, U. R. | |
| Author | SILVEIRA, S. M. M. | |
| Author | Albuquerque, G. D. M. | |
| Author | Mello, M. J. G. | |
| Author | Lopes, K. G. S. | |
| Author | Cordeiro, M. T. | |
| Author | Marques Jr., E. T. A. | |
| Author | Martelli, C. M. T. | |
| Author | Braga, C. | |
| Access date | 2025-02-12T13:42:51Z | |
| Available date | 2025-02-12T13:42:51Z | |
| Document date | 2017 | |
| Citation | CASTANHA, P. M. S. et al. Incidence and risk factors for dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort. Epidemiology & Infection, v. 145, n. 14, p. 2971-2979, 2017. | en_US |
| ISSN | 2752-8073 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68523 | |
| Language | eng | en_US |
| Publisher | Cambridge University Press | en_US |
| Rights | open access | en_US |
| Title | Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort | en_US |
| Type | Article | en_US |
| DOI | 10.1017/S095026881700214X | |
| Abstract | This study assessed the incidence and risk factors for dengue virus (DENV) infection among children in a prospective birth cohort conducted in the city of Recife, a hyperendemic dengue
area in Northeast Brazil. Healthy pregnant women (n=415) residing in Recife who agreed to have their children followed were enrolled. Children were followed during their first 24 months of age (May/2011–June/2014), before the 2015 Zika virus outbreak. DENV infection was detected by reverse-transcriptase polymerase chain reaction and/or serology (anti-DENV IgM/IgG). The incidence rates per 1000 person-years (py) and its association with risk factors by age bands (0–12, >12–30 months) were estimated through Poisson regression models. Forty-nine dengue infections were detected; none progressed to severe forms. The incidence rates were 107·6/1000py (95% CI 76·8–150·6) and 93·3/1000py (95% CI 56·1–154·4) in the first and second years of age, respectively. Male children (risk ratios (RR) = 2·33; 95% CI 1·09–4·98) and those born to DENV-naïve mothers (RR=2·42; 95% CI 1·01–5·80) were at greater risk of infection in the first year of age. In the second year, children born to Caucasian/Asian descent skin colour mothers had a threefold higher risk of infection (RR=3·34; 95% CI: 1·08–10·33). These data show the high exposure of children to DENV infection in our setting and highlight the role of biological factors in this population’s susceptibility to infection. | en_US |
| Affilliation | Fundação Oswaldo Crruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciência Médica. Instituto de Ciência Biologica. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Faculdade de Ciência Médica. Instituto de Ciência Biologica. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PE, USA /University of Pittsburgh. Department of Infectious Disease and Microbiology. Pittsburgh, PE, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Recife, PE, Brasil. | en_US |
| Subject | Children | en_US |
| Subject | Cohort | en_US |
| Subject | Dengue virus | en_US |
| Subject | Incidence | en_US |
