| Author | Petribu, Natacha Calheiros de Lima | |
| Author | Aragao, Maria de Fatima Vasco | |
| Author | Linden, Vanessa van der | |
| Author | Parizel, Paul | |
| Author | Jungmann, Patricia | |
| Author | Araújo, Luziany | |
| Author | Abath, Marília | |
| Author | Fernandes, Andrezza | |
| Author | Brainer-Lima, Alessandra | |
| Author | Holanda, Arthur | |
| Author | Mello, Roberto | |
| Author | Sarteschi, Camila | |
| Author | Duarte, Maria do Carmo Menezes Bezerra | |
| Access date | 2025-02-12T14:17:05Z | |
| Available date | 2025-02-12T14:17:05Z | |
| Document date | 2017 | |
| Citation | DE LIMA PETRIBU, Natacha Calheiros et al. Follow-up brain imaging of 37 children with congenital Zika syndrome: case series study. bmj, v. 359, 2017. | en_US |
| ISSN | 1756-1833 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68525 | |
| Language | eng | en_US |
| Publisher | BMJ Group | en_US |
| Rights | open access | en_US |
| Title | Follow-up brain imaging of 37 children with congenital Zika syndrome: case series study | en_US |
| Type | Article | en_US |
| DOI | 10.1136/bmj.j4188 | |
| Abstract | OBJECTIVE To compare initial brain computed tomography (CT) scans with follow-up CT scans at one year in children with congenital Zika syndrome, focusing on cerebral calcifications.
DESIGN Case series study. SETTING Barão de Lucena Hospital, Pernambuco state, Brazil. PARTICIPANTS 37 children with probable or confirmed congenital Zika syndrome during the microcephaly outbreak in 2015 who underwent brain CT shortly after birth and at one year follow-up. MAIN OUTCOME MEASURE Differences in cerebral calcification patterns between
initial and follow-up scans. RESULTS 37 children were evaluated. All presented cerebral calcifications on the initial scan, predominantly at cortical-white matter junction. At follow-up the
calcifications had diminished in number, size, or density, or a combination in 34 of the children (92%, 95% confidence interval 79% to 97%), were no longer visible in one child, and remained unchanged in two children. No child showed an increase in calcifications. The calcifications at the cortical white matter junction which were no longer visible
at follow-up occurred predominately in the parietal and occipital lobes. These imaging changes were not associated with any clear clinical improvements. CONCLUSION The detection of cerebral calcifications should not be considered a major criterion for late diagnosis of congenital Zika syndrome, nor should the absence of calcifications be used to exclude the diagnosis. | en_US |
| Affilliation | Hospital Barão de Lucena. Recife, PE, Brasil / Faculdade Pernambucana de Saúde. Recife, PE, Brasil. | en_US |
| Affilliation | Centro Diagnóstico Multimagem. Recife, PE, Brasil / Universidade Católica de Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Hospital Barão de Lucena. Recife, PE, Brasil / Associação de Assistência à Criança Deficiente. Recife, PE, Brasil | en_US |
| Affilliation | ntwerp University Hospital. Edegem, Belgium. | en_US |
| Affilliation | Universidade de Pernambuco. Departamento de Patologia. Recife, PE, Brasil. | en_US |
| Affilliation | Hospital Barão de Lucena. Recife, PE, Brasil. | en_US |
| Affilliation | Hospital Barão de Lucena. Recife, PE, Brasil. | en_US |
| Affilliation | Hospital Barão de Lucena. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Pronto-Socorro Cardiológico Universitário de Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Escola de Medicina. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Escola de Medicina. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Hospital Esperança, Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Recife, PE, Brasil. | en_US |
| Subject | Children | en_US |
| Subject | Zika syndrome: | en_US |
| Subject | Case series study | en_US |
