| Author | Silva, Gabrielle L. S. | |
| Author | Oliveira, Laura L. S. | |
| Author | Silva, Fredson Vieira e | |
| Author | Camargos, Murilo O. | |
| Author | Libório, Matheus Pereira | |
| Author | D'Angelo, Marcos Flávio Silveira Vasconcelos | |
| Author | Caldeira, Alisson Samuel Portes | |
| Author | Miralles-Pechuán, Luis | |
| Author | Rabiei, Hamid | |
| Access date | 2025-02-12T16:13:46Z | |
| Available date | 2025-02-12T16:13:46Z | |
| Document date | 2024 | |
| Citation | SILVA, Gabriele L. S. et al. Analyzing Morinda citrifolia’s Potential for Haemonchus contortus Control in Lambs Using an Artificial Immune/Neural Approach. IEEE, v. 12, p. 122462-122473, 2024. | en_US |
| ISSN | 2169-3536 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68530 | |
| Language | eng | en_US |
| Publisher | Institute of Electrical and Electronics Engineers | en_US |
| Rights | open access | en_US |
| Title | Analyzing Morinda citrifolia’s Potential for Haemonchus contortus Control in Lambs Using an Artificial Immune/Neural Approach. | en_US |
| Type | Article | en_US |
| DOI | 10.1109/access.2024.3451363 | |
| Abstract | Sheep farming faces significant health challenges, particularly from gastrointestinal nematodes like Haemonchus contortus, which can severely impact animal health. In response, there is growing interest in herbal medicines derived from medicinal plants as alternative solutions for parasite control. This approach offers multiple benefits, including local availability, reduced risk of anthelmintic resistance, decreased dependency on synthetic chemical treatments, and improved shelf life. Among the promising alternatives, Morinda citrifolia has shown potential for effective nematode control. This study evaluates the anthelmintic efficacy of the hydroalcoholic crude extract (EHMC) of Morinda citrifolia using a clustering approach based on an Artificial Immune/Neural System to determine the optimal dosage. The findings reveal that the EHMC of Morinda citrifolia inhibits the hatching of Haemonchus contortus eggs, increases the mortality of adult nematodes, and demonstrates anthelmintic activity in lambs without causing adverse effects on animal health or negatively impacting meat quality. This suggests that Morinda citrifolia extract is a promising natural alternative for controlling parasitic infections in sheep. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Departamento de Ciências Agrárias. Montes Claros, MG, Brasil. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Departamento de Ciências Agrárias. Montes Claros, MG, Brasil. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Departamento de Ciências Agrárias. Montes Claros, MG, Brasil. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Programa de Pós-Graduação em Modelagem de Computadores e Sistemas. Montes Claros, MG, Brasil. | en_US |
| Affilliation | Pontifícia Universidade Católica de Minas Gerais. Instituto de Educação Continuada. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Departamento de Ciência da Computação. Montes Claros, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | School of Computer Science. Technological University Dublin. Dublin, Ireland. | en_US |
| Affilliation | School of Architecture. Planning and Environmental Policy. University College Dublin. Dublin, Ireland. | en_US |
| Subject | Antibodies | en_US |
| Subject | Antigens | en_US |
| Subject | Cloning | en_US |
| Subject | Gastrointestinal tract | en_US |
| Subject | Animals | en_US |
| Subject | Clustering algorithms | en_US |
| Subject | Chemicals | en_US |
| Subject | Artificial immune/neural system | en_US |
| Subject | morinda citrifolia | en_US |
| Subject | haemonchus contortus control | en_US |
| Embargo date | 2030-12-31 | |
