| Author | Kasai, Shinji | |
| Author | Caputo, Beniamino | |
| Author | Tsunoda, Takashi | |
| Author | Cuong, Tran Chi | |
| Author | Maekawa, Yoshihide | |
| Author | Lam-Phua, Sai Gek | |
| Author | Pichler, Verena | |
| Author | Itokawa, Kentaro | |
| Author | Murota, Katsunori | |
| Author | Komagata, Osamu | |
| Author | Yoshida, Chigusa | |
| Author | Chung, Han-Hsuan | |
| Author | Bellini, Romeo | |
| Author | Tsuda, Yoshio | |
| Author | Teng, Hwa-Jen | |
| Author | Lima Filho, José Luiz de | |
| Author | Alves, Luiz Carlos | |
| Author | Ching, Lee | |
| Author | Minakawa, Noboru | |
| Author | Yen, Nguyen Thi | |
| Author | Phong, Tran Vu | |
| Author | Sawabe, Kyoko | |
| Author | Tomita, Takashi | |
| Access date | 2025-02-13T13:44:36Z | |
| Available date | 2025-02-13T13:44:36Z | |
| Document date | 2019 | |
| Citation | KASAI, Shinji et al. First detection of a Vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases. Eurosurveillance, v. 24, n. 5, p. 1700847, 2019. | en_US |
| ISSN | 1560-7917 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68544 | |
| Language | eng | en_US |
| Publisher | European Centre for Disease Prevention and Control | en_US |
| Rights | open access | en_US |
| Title | First detection of a Vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases | en_US |
| Type | Article | en_US |
| DOI | 10.2807/1560-7917.ES.2019.24.5.1700847 | |
| Abstract | Introduction: Aedes albopictus (Skuse) is an impor tant vector of arboviral diseases, including dengue, chikungunya and Zika virus disease. Monitoring insecticide resistance and mechanisms by which the mosquito develops resistance is crucial to minimise disease transmission. Aim: To determine insecticide resistance status and mechanisms in Ae. albopic tus from different geographical regions. Methods: We sampled 33 populations of Ae. albopictus from Asia,
Europe and South America, and tested these for sus ceptibility to permethrin, a pyrethroid insecticide. In resistant populations, the target site for pyrethroids, a voltage-sensitive sodium channel (Vssc) was geno typed. Three resistant sub-strains, each harbouring a resistance allele homozygously, were established and susceptibilities to three different pyrethroids (with and without a cytochrome P450 inhibitor) were assayed. Results: Most populations of Ae. albopic tus tested were highly susceptible to permethrin but a few from Italy and Vietnam (4/33), exhibited high-level resistance. Genotyping studies detected a knockdown resistance (kdr) allele V1016G in Vssc for the first time
in Ae. albopictus. Two previously reported kdr alleles, F1534C and F1534S, were also detected. The bioassays indicated that the strain homozygous for the V1016G allele showed much greater levels of pyrethroid resist ance than other strains harbouring F1534C or F1534S. Conclusion: The V1016G allele was detected in both Asian and Italian Ae. albopictus populations, thus a spread of this allele beyond Italy in Europe cannot be ruled out. This study emphasises the necessity to fre quently and regularly monitor the V1016G allele in Ae. albopictus, particularly where this mosquito species is the main vector of arboviruses. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | Università di Roma ‘La Sapienza’. Department of Public Health and Infectious Diseases. Parasitology Unit. Rome, Italy. | en_US |
| Affilliation | Nagasaki University. Department of Vector Ecology and Environment. Nagasaki, Japan. | en_US |
| Affilliation | National Institute of Hygiene and Epidemiology. Medical Entomology and Zoology Department. Hanoi, Vietnam. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | National Environment Agency. Environmental Health Institute. Singapore. | en_US |
| Affilliation | Università di Roma ‘La Sapienza’. Department of Public Health and Infectious Diseases. Parasitology Unit. Rome, Italy. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan / Japan Agency for Medical Research and Development. Department of Research Promotion. Tokyo, Japan. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan / Japan Agency for Medical Research and Development. Department of Research Promotion. Tokyo, Japan. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | Ministry of Health and Welfare. Centers for Disease Control. Center for Diagnostics and Vaccine Development. Taiwan. | en_US |
| Affilliation | Agriculture and Environment Centre “G. Nicoli”. Crevalcore, Italy. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | Ministry of Health and Welfare. Centers for Disease Control. Center for Diagnostics and Vaccine Development. Taiwan. | en_US |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Japan Agency for Medical Research and Development. Department of Research Promotion. Tokyo, Japan. | en_US |
| Affilliation | Nagasaki University. Department of Vector Ecology and Environment. Nagasaki, Japan. | en_US |
| Affilliation | National Institute of Hygiene and Epidemiology. Medical Entomology and Zoology Department. Hanoi, Vietnam. | en_US |
| Affilliation | National Institute of Hygiene and Epidemiology. Medical Entomology and Zoology Department. Hanoi, Vietnam. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Affilliation | National Institute of Infectious Diseases. Department of Medical Entomology. Tokyo, Japan. | en_US |
| Subject | V1016G | en_US |
| Subject | Aedes albopictus | en_US |
| Subject | Emerging threat | en_US |
