| Author | Eulálio, Kelsen Dantas | |
| Author | Kollath, Daniel R. | |
| Author | Martins, Liline Maria Soares | |
| Author | Deus Filho, Antonio de | |
| Author | Cavalcanti, Maria do Amparo Salmito | |
| Author | Moreira, Lucas Machado | |
| Author | Tenório, Bernardo Guerra | |
| Author | Alves, Lucas Gomes de Brito | |
| Author | Yamauchi, Danielle | |
| Author | Barrozo, Ligia Vizeu | |
| Author | Iii, George R. Thompson | |
| Author | Nacher, Mathieu | |
| Author | Stajich, Jason E. | |
| Author | Benard, Gil | |
| Author | Bagagli, Eduardo | |
| Author | Felipe, Maria Sueli Soares | |
| Author | Barker, Bridget M. | |
| Author | Trilles, Luciana | |
| Author | Teixeira, Marcus de Melo | |
| Access date | 2025-02-17T03:51:22Z | |
| Available date | 2025-02-17T03:51:22Z | |
| Document date | 2024 | |
| Citation | EULÁLIO, Kelsen Dantas et al. Epidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil. Nature Communications, v. 15, n. 1, p. 1-11, Apr. 2024. | en_US |
| ISSN | 2041-1723 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68586 | |
| Language | eng | en_US |
| Publisher | Nature | en_US |
| Rights | open access | en_US |
| Title | Epidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41467-024-47388-0 | |
| Abstract | Coccidioidomycosis, listed as a priority mycosis by the WHO, is endemic in the United States but often overlooked in Central and South America. Employing a multi-institutional approach, we investigate how disease characteristics, pathogen genetic variation, and environmental factors impact coccidioidomycosis epidemiology and outcomes in South America. We identified 292 cases (1978-2021) and 42 outbreaks in Piauí and Maranhão states, Brazil, the largest series outside the US/Mexico epidemic zone. The male-to-female ratio was 57.4:1 and the most common activity was armadillo hunting (91.1%) 4 to 30 days before symptom onset. Most patients (92.8%) exhibited typical acute pulmonary disease, with cough (93%), fever (90%), and chest pain (77%) as predominant symptoms. The case fatality rate was 8%. Our negative binomial regression model indicates that reduced precipitation levels in the current (p = 0.015) and preceding year (p = 0.001) predict heightened incidence. Unlike other hotspots, acidic soil characterizes this region. Brazilian strains differ genomically from other C. posadasii lineages. Northeastern Brazil presents a distinctive coccidioidomycosis profile, with armadillo hunters facing elevated risks. Low annual rainfall emerges as a key factor in increasing cases. A unique C. posadasii lineage in Brazil suggests potential differences in environmental, virulence, and/or pathogenesis traits compared to other Coccidioides genotypes. | en_US |
| Affilliation | Universidade Federal do Piauí. Hospital de Doenças Infecto Contagiosas. Teresina, PI, Brasil. | en_US |
| Affilliation | Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, AZ, USA. | en_US |
| Affilliation | Universidade Federal do Piauí. Hospital de Doenças Infecto Contagiosas. Teresina, PI, Brasil. | en_US |
| Affilliation | Universidade Federal do Piauí. Hospital de Doenças Infecto Contagiosas. Teresina, PI, Brasil. | en_US |
| Affilliation | Universidade Federal do Piauí. Hospital de Doenças Infecto Contagiosas. Teresina, PI, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | University of Brasília. Faculty of Medicine. Brasília, DF, Brazil. | en_US |
| Affilliation | University of Brasília. Faculty of Medicine. Brasília, DF, Brazil. | en_US |
| Affilliation | Universidade Estadual Paulista. Instituto de Biociências de Botucatu. Departamento de Microbiologia e Imunologia. Botucatu, SP, Brasil. | en_US |
| Affilliation | University of São Paulo. Faculty of Philosophy, Languages and Literature, and Human Sciences. Department of Geography. São Paulo, SP, Brazil. | en_US |
| Affilliation | Department of Internal Medicine. Division of Infectious Diseases and Department of Medical Microbiology and Immunology. UC-Davis, Sacramento, CA, USA. | en_US |
| Affilliation | Centre d'Investigations Cliniques. INSERM 1424. Centre hospitalier de Cayenne - French Guiana. Cayenne, French Guiana. | en_US |
| Affilliation | University of California-Riverside. Department of Microbiology and Plant Pathology. Riverside, CA, USA. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. Departamento de Dermatologia. Laboratório de Micologia Médica. São Paulo, SP, Brasil. | en_US |
| Affilliation | Universidade Estadual Paulista. Instituto de Biociências de Botucatu. Departamento de Microbiologia e Imunologia. Botucatu, SP, Brasil. | en_US |
| Affilliation | Universidade Católica de Brasília. Brasília, DF, Brasil. | en_US |
| Affilliation | Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, AZ, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, AZ, USA / University of Brasília. Faculty of Medicine. Brasília, DF, Brazil. | en_US |
| Subject | Coccidioidomycosis | en_US |
| Subject | Organização Mundial de Saúde (OMS) | en_US |
| Subject | United States | en_US |
| Subject | Central and South America | en_US |
| e-ISSN | 2041-1723 | |
