| Author | Nicacio, Jandir Mendonça | |
| Author | Souza, Carlos Dornels Freire de | |
| Author | Khouri, Ricardo | |
| Author | Pereira, Vanessa Cardoso | |
| Author | Carmo, Rodrigo Feliciano do | |
| Author | Patriota, Pedro Vinícius Amorim de Medeiros | |
| Author | Nunes, Sávio Luiz Pereira | |
| Author | Morais Júnior, Jeová Cordeiro de | |
| Author | Barral Netto, Manoel | |
| Author | Lima, João Augusto Costa | |
| Author | Armstrong, Anderson da Costa | |
| Access date | 2025-02-18T14:10:38Z | |
| Available date | 2025-02-18T14:10:38Z | |
| Document date | 2025 | |
| Citation | NICACIO, Jandir Mendonça et al. Arbovirus exposure and subclinical myocardial dysfunction in an Indigenous population in Northeast Brazil: a cross-sectional study. BMC Infectious Diseases, v. 25, n. 89, p. 1-12, 2025. | en_US |
| ISSN | 1471-2334 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68606 | |
| Sponsorship | Ministério da Ciência, Tecnologia, Inovações e Comunicações do Brasil.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
| Language | eng | en_US |
| Publisher | BioMed Central | en_US |
| Rights | open access | en_US |
| Title | Arbovirus exposure and subclinical myocardial dysfunction in an Indigenous population in Northeast Brazil: a cross-sectional study | en_US |
| Type | Article | en_US |
| DOI | 10.1186/s12879-024-10320-4 | |
| Abstract | Background: Human activities, such as urbanization and climate change, have facilitated the spread of arbovirus-carrying vectors, disproportionately affecting vulnerable traditional Indigenous communities. Objective: To explore the relationships between subclinical myocardial dysfunction, assessed by global longitudinal strain (GLS), and comprehensive arbovirus serology in an Indigenous population, while also describing the serological and epidemiological profile of dengue, chikungunya, and Zika viruses. Methods: This ancillary study is part of the first phase (2016–2017) of the Project of Atherosclerosis among Indigenous Populations (PAI), a cross-sectional study involving participants from two Indigenous communities with different degrees of urbanization and a highly urbanized city in Northeast Brazil. We assessed the seroprevalence of dengue, chikungunya, and Zika viruses in the Fulni-ô Indigenous community, the less urbanized and most traditional group. Additionally, we explored the relationship between these viruses and subclinical heart disease, assessed by speckle-tracking echocardiography-derived GLS. Results: One hundred seventy-four participants were included, with a median age of 45.0 years (interquartile range 38.0–55.0). The majority were female (58.6%; n = 102). The prevalence of anti-ZIKV IgG was 95.3%; anti-DENV IgG was 85.8%, and anti-CHIKV IgG was 70.9%. GLS abnormalities were detected in nearly half (48.3%) of the cohort. However, no significant association was found between arbovirus serology and GLS. Conclusions: The findings reveal a high prevalence of positive serology for arboviruses and a significant rate of subclinical cardiac dysfunction. There was no significant association between reduced left ventricular longitudinal strain and positive arbovirus serology, likely due to the limited number of participants with indications of acute contact with the viruses studied. However, the unprecedented and relevant results of this study are noteworthy, as they address critical public health issues, particularly in vulnerable populations. Further research is needed to explore these findings in more depth. | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil / Universidade Estadual da Bahia. Programa de Pós-Graduação em Ecologia Humana e Gestão Socioambiental. Juazeiro, BA, Brasil / Universidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil. | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil / Fundação Oswaldo Cruz. Programa de Pós-Graduação em Epidemiologia e Controle de Problemas de Saúde. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Rega Institute for Medical Research. KU Leuven, Leuven, Belgium. | en_US |
| Affilliation | Universidade Estadual da Bahia. Programa de Pós-Graduação em Ecologia Humana e Gestão Socioambiental. Juazeiro, BA, Brasil. | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil. | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade de São Paulo. Instituto Nacional de Ciência e Tecnologia para Pesquisa em Imunologia. São Paulo, SP, Brasil. | en_US |
| Affilliation | Cardiology. Johns Hopkins University. Baltimore, MD, USA | en_US |
| Affilliation | Universidade Federal do Vale do São Francisco. Faculdade de Medicina. Petrolina, PE, Brasil / Universidade Estadual da Bahia. Programa de Pós-Graduação em Ecologia Humana e Gestão Socioambiental. Juazeiro, BA, Brasil. | en_US |
| Subject | Indigenous population | en_US |
| Subject | Arbovirus | en_US |
| Subject | Global longitudinal strain | en_US |
| Subject | Dengue | en_US |
| Subject | Chikungunya | en_US |
| Subject | Zika | en_US |
| DeCS | Povos indígenas | en_US |
| DeCS | Arbovírus | en_US |
| DeCS | Deformação longitudinal global | en_US |
| DeCS | Dengue | en_US |
| DeCS | Vírus chikungunya | en_US |
| DeCS | Zika virus | en_US |
