| Author | Ali, Sobur | |
| Author | Giovanetti, Marta | |
| Author | Johnston, Catherine | |
| Author | Urdaneta-Páez, Verónica | |
| Author | Azarian, Taj | |
| Author | Cella, Eleonora | |
| Access date | 2025-02-18T16:16:39Z | |
| Available date | 2025-02-18T16:16:39Z | |
| Document date | 2024 | |
| Citation | ALI, Sobur et al. From emergence to evolution: dynamics of the SARS-CoV-2 omicron variant in Florida. Pathogens, v. 13, n. 12, p. 1-11, 12 Dec. 2024. | |
| ISSN | 2076-0817 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68618 | |
| Description | Produção científica do Laboratório de Arbovírus e Vírus Hemorrágicos. | pt_BR |
| Description | Link para a revisão do artigo: https://www.mdpi.com/2076-0817/13/12/1095/review_report | pt_BR |
| Sponsorship | This work was funded in part by a grant from the Rockefeller Foundation to the University of Florida and the University of Central Florida in order to accelerate regional genomic surveillance. The views and findings are those of the authors and not those of the funder (the Rockefeller Foundation). Marta Giovanetti's funding was provided by PON "Ricerca e Innovazione" 2014–2020 and by the CRP-ICGEB RESEARCH GRANT 2020 Project CRP/BRA20-03, Contract CRP/20/03. | |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | From emergence to evolution: dynamics of the SARS-CoV-2 omicron variant in Florida | en_US |
| Type | Article | |
| DOI | 10.3390/pathogens13121095 | |
| Abstract | The continual evolution of SARS-CoV-2 has significantly influenced the global response to the COVID-19 pandemic, with the emergence of highly transmissible and immune-evasive variants posing persistent challenges. The Omicron variant, first identified in November 2021, rapidly replaced the Delta variant, becoming the predominant strain worldwide. In Florida, Omicron was first detected in December 2021, leading to an unprecedented surge in cases that surpassed all prior waves, despite extensive vaccination efforts. This study investigates the molecular evolution and transmission dynamics of the Omicron lineages during Florida’s Omicron waves, supported by a robust dataset of over 1000 sequenced genomes. Through phylogenetic and phylodynamic analyses, we capture the rapid diversification of the Omicron lineages, identifying significant importation events, predominantly from California, Texas, and New York, and exportation to North America, Europe, and South America. Variants such as BA.1, BA.2, BA.4, and BA.5 exhibited distinct transmission patterns, with BA.2 showing the ability to reinfect individuals previously infected with BA.1. Despite the high transmissibility and immune evasion of the Omicron sub-lineages, the plateauing of cases by late 2022 suggests increasing population immunity from prior infection and vaccination. Our findings underscore the importance of continuous genomic surveillance in identifying variant introductions, mapping transmission pathways, and guiding public health interventions to mitigate current and future pandemic risks. | en_US |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | Università Campus Bio-Medico di Roma. Department of Sciences and Technologies for Sustainable Development and One Health. Roma, Italy / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Subject | SARS-CoV-2 | en_US |
| Subject | Genomic surveillance | en_US |
| Subject | Molecular epidemiology | en_US |
| Subject | Florida | en_US |
| Subject | United States | en_US |
| e-ISSN | 2076-0817 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
