| Author | Ayres, Ana Beatriz Nascimento | |
| Author | Travassos Junior, Xisto Lucas | |
| Author | Savino, Wilson | |
| Author | Herculano, Edla de Azevedo | |
| Author | Sampaio, Renelson Ribeiro | |
| Access date | 2025-02-18T17:32:05Z | |
| Available date | 2025-02-18T17:32:05Z | |
| Document date | 2024 | |
| Citation | AYRES, Ana Beatriz Nascimento et al. The role of stakeholders in the development of ChAdOx1-S COVID-19 vaccine. Discover Public Health, v. 21, n. 232, p. 1-14, 11 Dec. 2024. | |
| ISSN | 3005-0774 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68622 | |
| Description | Produção científica do Laboratório de Pesquisa sobre o Timo. | pt_BR |
| Sponsorship | The authors [Ana Beatriz Nascimento Ayres e Wilson Savino] would like to thank [Oswaldo Cruz Fundation] for the institutional support granted during the execution of this manuscript, carried out within the institution's work framework. Furthermore, this work received financial support from [Oswaldo Cruz Fundation], which contributed to its completion. Not applied to other authors. | |
| Language | eng | en_US |
| Publisher | Springer | |
| Publisher | Discover | |
| Rights | open access | |
| Title | The role of stakeholders in the development of ChAdOx1-S COVID-19 vaccine | en_US |
| Type | Article | |
| DOI | 10.1186/s12982-024-00356-x | |
| Abstract | COVID-19, an infectious disease caused by the virus SARS-CoV-2, has become a global pandemic and has been classified as a Public Health Emergency of International Concern. Considering vaccines as an effective action to shorten viral transmission and to reduce mortality, stakeholders have worked together to develop vaccines, which played a vital role in containing this pandemic worldwide. In the development of the adenovirus-based ChAdOx1-S vaccine, it is interesting to note the speed at which it was created, with safety, breaking paradigms, relying on connections and influences at various levels, showing that a vaccine can be produced in a very short period of time if specific stakeholder dynamics is engaged. Herein, we combined the concepts and methods of Stakeholder Theory and Social Network Analysis within this complex scenario, indeed, the positive results delivered to society reinforce the principles of the Stakeholder Theory. Moreover, Social Network Analysis revealed that the ChAdOx1-S vaccine ecosystem had 30 nodes of interconnection. Overall, the data summarized presently discussed indicate the need for preparedness within the vaccine development ecosystem, important for future research into the management and development process of vaccines designed to cope with future global or regional health emergencies. Key points related to the complexity of a health emergency, considering its risks to public health and society. A coordinated, interdisciplinary, and systemic response between the different actors is emphasized. This study focuses on analyzing the actors involved in the activities related to the development of the ChAdOx1-S vaccine against COVID-19, taking into account the paradigms of time and specificity of the pandemic emergency. Considering the network analysis, for this vaccine, new institutional arrangements have emerged, significantly expanding the limits of knowledge, since the initial research was based on more than a decade of knowledge production. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Presidência. Coordenação de Comunicação Social. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Santa Catarina. Florianópolis, SC, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Serviço Nacional de Aprendizagem Industrial. Centro Integrado de Manufatura e Tecnologia. Departamento Regional da Bahia. Salvador, BA, Brasil. | |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | ChAdOx1-S vaccine | en_US |
| Subject | Stakeholder | en_US |
| DeCS | ChAdOx1 nCoV-19 | pt_BR |
| e-ISSN | 3005-0774 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
