| Author | Ribeiro, Marcia | |
| Author | Cardozo, Ludmila F. M. F. | |
| Author | Fanton, Susane | |
| Author | Germer, Beatriz | |
| Author | Paiva, Bruna R. | |
| Author | Alvarenga, Livia | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Mafra, Denise | |
| Access date | 2025-02-25T03:33:03Z | |
| Available date | 2025-02-25T03:33:03Z | |
| Document date | 2024 | |
| Citation | RIBEIRO, Marcia et al. Zinc status and inflammation in patients on hemodialysis: a cross‑sectional observational study. Nutrire, v. 49, n. 58, p. 1-7, Nov. 2024. | en_US |
| ISSN | 2316-7874 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68708 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) support Denise Mafra´s research. | en_US |
| Language | eng | en_US |
| Publisher | Springer | en_US |
| Rights | restricted access | |
| Title | Zinc status and inflammation in patients on hemodialysis: a cross‑sectional observational study | en_US |
| Type | Article | |
| DOI | 10.1186/s41110-024-00299-y | |
| Abstract | Purpose Zinc plays a vital role in the body, including inflammation and oxidative stress mitigation, which are common com plications in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This cross-sectional observational study evaluated the correlation between zinc status and inflammatory markers in patients undergoing HD. Methods Twenty patients (ten men, 50 (14.5) years, and BMI of 26.7 (6.8) kg/m2) were evaluated. Plasma and erythrocyte zinc levels were measured by inductively coupled plasma mass spectrometry (ICP-MS). Nrf2 and NF-kB mRNA expressions were assessed in PBMCs using quantitative real-time polymerase chain reaction (RT-qPCR), and malondialdehyde (MDA) plasma level was used as a lipid peroxidation marker. Routine biochemical parameters, including C-reactive protein (CRP) levels, were assessed by commercial BioClin® kits. Results As expected, we observed a tendency to have an inverse correlation between erythrocyte and plasma zinc (Zn) levels (rho = − 0.41, p = 0.06). The CRP plasma levels were negatively associated with Zn plasma levels (rho = − 0.53, P = 0.01) after age, time on dialysis, sex, and BMI adjustment. Conclusion A negative correlation was observed between plasma Zn levels and a marker of inflammation (CRP), suggesting a possible role of Zn in the inflammation status of these patients. Trial registration ClinicalTrials.gov Identifier: NCT04600258. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Program in Biological Sciences – Physiology. Rio de Janeiro, RJ, Brazil / Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil. | en_US |
| Affilliation | Fluminense Federal University. Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Program in Biological Sciences – Physiology. Rio de Janeiro, RJ, Brazil / Fluminense Federal University. Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Subject | Zinc | en_US |
| Subject | Chronic kidney disease | en_US |
| Subject | Inflammation | en_US |
| Subject | Hemodialysis | en_US |
| e-ISSN | 2316-7874 | |
| Embargo date | 2030-12-31 | |
