| Author | Pinto, Matheus de Oliveira Silva | |
| Author | Pereira, Leonardo de Paula | |
| Author | Angelo, Ana Luiza Pessoa de Mendonça | |
| Author | Xavier, Marcelo Antônio Pascoal | |
| Author | Machado, Alexandre de Magalhães Vieira | |
| Author | Russo, Remo Castro | |
| Access date | 2025-02-25T14:11:22Z | |
| Available date | 2025-02-25T14:11:22Z | |
| Document date | 2025 | |
| Citation | PINTO, Matheus de Oliveira Silva et al. Dissecting the COVID-19 Immune Response: Unraveling the Pathways of Innate Sensing and Response to SARS-CoV-2 Structural Proteins. Journal of molecular recognition: JMR, v. 38, n. 2, p. 1-32, Mar. 2025. | en_US |
| ISSN | 0952-3499 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68718 | |
| Language | eng | en_US |
| Publisher | John Wiley & Sons | en_US |
| Rights | restricted access | |
| Title | Dissecting the COVID-19 Immune Response: Unraveling the Pathways of Innate Sensing and Response to SARS-CoV-2 Structural Proteins | en_US |
| Type | Article | |
| DOI | 10.1002/jmr.70002 | |
| Abstract | Severe acute respiratory syndrome coronavirus (SARS-CoV), the virus responsible for COVID-19, interacts with the host immune system through complex mechanisms that significantly influence disease outcomes, affecting both innate and adaptive immunity. These interactions are crucial in determining the disease's severity and the host's ability to clear the virus. Given the virus's substantial socioeconomic impact, high morbidity and mortality rates, and public health importance, understanding these mechanisms is essential. This article examines the diverse innate immune responses triggered by SARS-CoV-2's structural proteins, including the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins, along with nonstructural proteins (NSPs) and open reading frames. These proteins play pivotal roles in immune modulation, facilitating viral replication, evading immune detection, and contributing to severe inflammatory responses such as cytokine storms and acute respiratory distress syndrome (ARDS). The virus employs strategies like suppressing type I interferon production and disrupting key antiviral pathways, including MAVS, OAS-RNase-L, and PKR. This study also explores the immune pathways that govern the activation and suppression of immune responses throughout COVID-19. By analyzing immune sensing receptors and the responses initiated upon recognizing SARS-CoV-2 structural proteins, this review elucidates the complex pathways associated with the innate immune response in COVID-19. Understanding these mechanisms offers valuable insights for therapeutic interventions and informs public health strategies, contributing to a deeper understanding of COVID-19 immunopathogenesis. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, Brasil / Fundação Osvaldo Cruz. Instituto René Rachou. Grupo de Imunologia de Doenças Virais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, Brasil / Fundação Osvaldo Cruz. Instituto René Rachou. Grupo de Imunologia de Doenças Virais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Osvaldo Cruz. Instituto René Rachou. Grupo de Imunologia de Doenças Virais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Osvaldo Cruz. Instituto René Rachou. Grupo de Imunologia de Doenças Virais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Osvaldo Cruz. Instituto René Rachou. Grupo de Imunologia de Doenças Virais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, Brasil. | en_US |
| Subject | COVID‐19 | en_US |
| Subject | SARS‐CoV‐2 | en_US |
| Subject | Coronavirus | en_US |
| Subject | Immunity | en_US |
| Subject | Structural proteins | en_US |
| Embargo date | 2030-12-31 | |
