| Author | Brito-de-Sousa, Joaquim Pedro | |
| Author | Lima-Silva, Maria Luiza | |
| Author | Costa-Rocha, Ismael Artur da | |
| Author | Campi-Azevedo, Ana Carolina | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Faria, Ana Maria Caetano | |
| Author | Lima-Costa, Maria Fernanda | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Torres, Karen Cecília de Lima | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2025-02-26T19:45:58Z | |
| Available date | 2025-02-26T19:45:58Z | |
| Document date | 2025 | |
| Citation | BRITO-DE-SOUSA, Joaquim Pedro et al. Rhythms and shifts of chemokines and cytokines interplay in a decade lifespan: The longitudinal community-based Bambuí health and aging study. Experimental gerontology, 2025, 112700, 2025. | |
| URI | https://www.arca.fiocruz.br/handle/icict/68734 | |
| Language | eng | en_US |
| Publisher | Elsevier Science | |
| Rights | restricted access | |
| Subject in Portuguese | Citocinas | pt_BR |
| Title | Rhythms and shifts of chemokines and cytokines interplay in a decade lifespan: The longitudinal community-based Bambuí health and aging study | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.exger.2025.112700 | |
| Abstract | Aging is associated with several physiological changes, including a remarkable remodeling of the immune system. Herein, the rhythms and shifts in serum immune mediators were characterized in a decade lifespan as a longitudinal community-based prospective investigation from Bambuí Health and Aging Study. The study population included paired samples from 713 subjects survivors from the original BHAS cohort and at 10-years Follow-up, categorized into 5-years age range intervals (60-64Yrs towards 90 + Yrs). Quantification of soluble mediators were carried out by Cytometric Bead Array. The results demonstrated a rhythmic increase in serum immune mediators, especially CXCL9, CXCL10, IL-1β, IL-6 and TNF following the aging process, particularly at age intervals 70-74Yrs and 85-89Yrs. More prominent fold change magnitudes were observed for TNF (27.64×), CXCL9 (2.40×), IL-1β (2.20×), IL-6 (1.47×) and CXCL10 (1.26×). On the other hand, analysis of integrative networks showed a waning in the correlation numbers between immune mediators in a decade lifespan and a shift of connectivity from chemokines at Enrollment towards cytokines at 10-years Follow-up. Cross-correlation approaches revealed that CXCL9, CXCL10, IL-1β, IL-6 and IL-10 were placed in the innermost position, underscoring the higher contribution of these mediators along aging. Overall, these findings re-emphasize the impact of aging in the dynamic profile of serum immune mediators, highlighting the shift of selective mediators and their rhythmic signatures across chronological aging. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Gestão em Saúde. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / UNIFENAS, Belo Horizonte, MG, Brasil. | |
| Affilliation | Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brasil. / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Subject | Chemokines | en_US |
| Subject | Cytokines | en_US |
| Subject | Growth factors | en_US |
| Subject | Aging | en_US |
| Subject | Cohort | en_US |
| Embargo date | 3100-12-31 | |
