| Author | Campos, Fernanda Fraga | |
| Author | Johann, Susana | |
| Author | Cota, Betania Barros | |
| Author | Alves, Tânia Maria de Almeida | |
| Author | Rosa, Luiz Henrique | |
| Author | Caligiorne, Rachel Basques | |
| Author | Cisalpino, Patrícia Silva | |
| Author | Rosa, Carlos Augusto | |
| Author | Zani, Carlos Leomar | |
| Access date | 2013-09-13T18:54:24Z | |
| Available date | 2013-09-13T18:54:24Z | |
| Document date | 2010 | |
| Citation | CAMPOS, Fernanda Fraga et al. Antifungal activity of trichothecenes from Fusarium sp. against clinical isolates of Paracoccidioides brasiliensis. Mycoses, v. 54, n. 4, p. 122-129, Jul. 2011. | pt_BR |
| ISSN | 0933-7407 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6892 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Antifungal activity of trichothecenes from Fusarium sp. against clinical isolates of Paracoccidioides brasiliensis | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1439-0507.2009.01854.x | |
| Abstract | Paracoccidioidomycosis (PCM), a human mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis, is a serious public health problem in several countries of Latin America. In our search we found that the crude extract of the endophytic fungus UFMGCB 551 was able to inhibit several clinical strains of P. brasiliensis, and was also active in the bioautographic assay against Cladosporium sphaerospermum. The endophytic fungus UFMGCB 551 was isolated from the plant Piptadenia adiantoides J.F. Macbr (Fabaceae). The fungus was identified as Fusarium sp. based on its macro-and micro-morphology, and on the sequence of the internally transcribed spacer regions (ITS) of its rRNA gene. The chromatographic fractionation of the fungal extract was guided by the bioautographic assay to afford three known trichothecene mycotoxins: T2-toxin (1) and a mixture of 8-n-butyrylneosolaniol (2) and 8-isobutyrylsolaniol (3). The minimal inhibitory concentrations (MIC) of the these compounds against eleven clinical strains of P. brasiliensis were evaluated and found to be in the range between 75 and 640 nmol l)1 for 1 and 160–640 nmol l )1 for the mixture of 2and 3. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Laboratório de Microbiologia. Ouro Preto, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte. MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte. MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Paracoccidioides brasiliensis | pt_BR |
| Subject | Antifungal compounds | pt_BR |
| Subject | 8-n-butyrylneosolaniol | pt_BR |
| Subject | 8-isobutyrylneosolaniol | pt_BR |
| Subject | T2-toxin | pt_BR |
| Subject | Fusarium sp | pt_BR |
