| Author | Auld, Sara C. | |
| Author | Queiroz, Artur T. L. | |
| Author | Pereira, Mariana Araujo | |
| Author | Maenetje, Pholo | |
| Author | Mofokeng, Nomsa | |
| Author | Mngomezulu, Lerato | |
| Author | Masilela, Duduzile | |
| Author | Dobosh, Brian | |
| Author | Tirouvanziam, Rabindra | |
| Author | Kornfeld, Hardy | |
| Author | Andrade, Bruno B. | |
| Author | Bisson, Gregory P. | |
| Access date | 2025-03-25T17:28:52Z | |
| Available date | 2025-03-25T17:28:52Z | |
| Document date | 2024 | |
| Citation | AULD, Sara C. et al. Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection. MedRxiv, p. 1-12, 2024. | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69216 | |
| Sponsorship | National Institute of Health.
Center for AIDS Research at University of Pennsylvania.
Center for AIDS Research at Emory University . | en_US |
| Language | eng | en_US |
| Publisher | openRxiv | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Tuberculose | en_US |
| Subject in Portuguese | Infecções por HIV | en_US |
| Subject in Portuguese | Sangue | en_US |
| Subject in Portuguese | Escarro | en_US |
| Title | Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection | en_US |
| Type | Article | en_US |
| Abstract | Although tuberculosis (TB) remains a major killer among infectious diseases and the leading cause of death for people with HIV, drivers of immunopathology, particularly at the site of infection in the lungs remain incompletely understood. To fill this gap, we compared cytokine profiles in paired plasma and sputum samples collected from adults with pulmonary TB with and without HIV. We found that people with pulmonary TB with HIV had significantly higher markers of inflammation in both plasma and sputum than those without HIV; these differences were present despite a similar extent of radiographic involvement. We also found that the strength and direction of correlations between biomarkers in the blood and lung compartments differed by HIV status and people with HIV had more positive correlations than those without HIV. Future studies can further explore these differences in inflammation by HIV status across the blood and lung compartments and seek to establish how these profiles may be associated with long-term outcomes and lung health after completion of TB treatment. | en_US |
| Affilliation | Departments of Medicine. Epidemiology and Global Health. Emory University School of Medicine and Rollins School of Public Health. Atlanta, Georgia, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Multinational Organization Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Multinational Organization Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brazil / Instituto de Pesquisa Clínica e Translacional. Faculdade Zarns, Clariens Educação. Salvador, BA, Brasil. | en_US |
| Affilliation | The Aurum Institute. Johannesburg, South Africa / Department of Medicine. Vanderbilt University. Nashville, Tennessee, USA. | en_US |
| Affilliation | The Aurum Institute. Johannesburg, South Africa. | en_US |
| Affilliation | The Aurum Institute. Johannesburg, South Africa. | en_US |
| Affilliation | The Aurum Institute. Johannesburg, South Africa. | en_US |
| Affilliation | Department of Pediatrics. Emory University and Center for CF and Airways Disease Research. Children’s Healthcare of Atlanta. Atlanta, GA, USA. | en_US |
| Affilliation | Department of Pediatrics. Emory University and Center for CF and Airways Disease Research. Children’s Healthcare of Atlanta. Atlanta, GA, USA. | en_US |
| Affilliation | Department of Medicine. University of Massachusetts Chan Medical School. Worcester, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Multinational Organization Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Instituto de Pesquisa Clínica e Translacional. Faculdade Zarns, Clariens Educação. Salvador, BA, Brasil. | en_US |
| Affilliation | Department of Medicine and Department of Biostatistics. Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics. Perelman School of Medicine at the University of Pennsylvania. Philadelphia, Pennsylvania, USA. | en_US |
| Subject | Tuberculosis | en_US |
| Subject | HIV Infections | en_US |
| Subject | Blood | en_US |
| Subject | Sputum | en_US |
