| Author | Cassali, Geovanni Dantas | |
| Author | Nakagaki, Karen Yumi Ribeiro | |
| Author | Salvi, Marisa | |
| Author | Reys, Marina Possa dos | |
| Author | Rocha, Marcos André Nino | |
| Author | Campos, Cecilia Bonolo de | |
| Author | Ferreira, Enio | |
| Author | Rodrigues, Angelica Cavalheiro Bertagnolli | |
| Author | Reis, Diego Carlos dos | |
| Author | Damasceno, Karine Araújo | |
| Author | Estrela-Lima, Alessandra | |
| Access date | 2025-03-25T18:54:24Z | |
| Available date | 2025-03-25T18:54:24Z | |
| Document date | 2025 | |
| Citation | CASSALI, Geovanni Dantas et al. Canine, feline, and murine mammary tumors as a model for translational research in breast cancer. Veterinary Sciences, v. 12, n. 2, p. 1-26, 2025. | en_US |
| ISSN | 2306-7381 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69221 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | Canine, feline, and murine mammary tumors as a model for translational research in breast cancer | en_US |
| Type | Article | en_US |
| DOI | 10.3390/vetsci12020189 | |
| Abstract | In veterinary medicine, mammary tumors are the most common neoplasms in female dogs and the third most frequent in cats, representing a significant challenge. Efforts have been directed toward adopting standardized diagnostic criteria to better understand tumor behavior and progression in these species. Meanwhile, the use of animal models has substantially advanced the understanding of comparative mammary carcinogenesis. These models provide critical insights into factors responsible for the disease in humans, with the expectation that such factors can be identified and controlled. In this context, this review presents a work based mainly on articles published by a research group specializing in mammary pathology (Laboratory of Comparative Pathology–Department of General Pathology–ICB/UFMG) and its collaborators, complementing their results with literature findings. The publications were categorized into animal research, experimental research, and human research. These studies addressed topics such as diagnosis, prognostic and predictive factors, tumor microenvironment, inflammation associated with tumors, treatment approaches, and factors influencing tumor growth. The conceptual network analysis underscores the importance of in vivo breast cancer models, both experimental and spontaneous, for understanding tumor progression mechanisms and therapeutic responses, offering valuable contributions to veterinary and human oncology. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil. | en_US |
| Affilliation | Princess Margaret Cancer Centre. University Health Network. Toronto, Canada. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Instituto de Pesquisas Veterinárias Desidério Finamor. Eldorado do Sul, RS, Brasil. | en_US |
| Affilliation | Division of Molecular Pathology. The Institute of Cancer Research. London, UK. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil. | en_US |
| Subject | Mammary tumors | en_US |
| Subject | Mammary cancer | en_US |
| Subject | Histological grading | en_US |
| Subject | Tumor microenvironment | en_US |
| Subject | Translational models | en_US |
| Subject | Cancer treatment | en_US |
| DeCS | Neoplasias da Mama | en_US |
| DeCS | Gradação de Tumores | en_US |
| DeCS | Microambiente Tumoral | en_US |
