| Author | Messina, Nicole L. | |
| Author | Germano, Susie | |
| Author | Chung, Amy W. | |
| Author | Sandt, Carolien E. van de | |
| Author | Stevens, Natalie E. | |
| Author | Allen, Lilith F. | |
| Author | Bonnici, Rhian | |
| Author | Croda, Julio | |
| Author | Counoupas, Claudio | |
| Author | Grubor-Bauk, Branka | |
| Author | Haycroft, Ebene R. | |
| Author | Kedzierska, Katherine | |
| Author | McDonald, Ellie | |
| Author | McElroy, Rebecca | |
| Author | Netea, Mihai G. | |
| Author | Novakovic, Boris | |
| Author | Perrett, Kirsten P. | |
| Author | Pittet, Laure F. | |
| Author | Purcell, Ruth A. | |
| Author | Subbarao, Kanta | |
| Author | Triccas, James A. | |
| Author | Lynn, David J. | |
| Author | Curtis, Nigel | |
| Access date | 2025-03-27T17:45:23Z | |
| Available date | 2025-03-27T17:45:23Z | |
| Document date | 2025 | |
| Citation | MESSINA, Nicole L. et al. Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination. Clinical & Translational Immunology, v. 14, n. 1, p. 1-18, Jan. 2025. | en_US |
| ISSN | 2050-0068 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69272 | |
| Language | eng | en_US |
| Publisher | Wiley | en_US |
| Rights | open access | en_US |
| Title | Effect of Bacille Calmette–Guerin vaccination on immune responses to SARS-CoV-2 and COVID-19 vaccination | en_US |
| Type | Article | en_US |
| DOI | 10.1002/cti2.70023 | |
| Abstract | Objectives. Bacille Calmette–Guerin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to vaccines against SARS-CoV-2. Methods. Blood samples, from a subset of 275 SARS-CoV-2-na€ıve healthcare workers randomised to BCG vaccination (BCG group) or no BCG vaccination (Control group) in the BRACE trial, were collected before and 28 days after the primary course (two doses) of ChAdOx1-S (Oxford-AstraZeneca) or BNT162b2 (Pfizer-BioNTech) vaccination. SARS-CoV-2-specific antibodies were measured using ELISA and multiplex bead array, whole blood cytokine responses to c-irradiated SARS-CoV-2 (iSARS) stimulation were measured by multiplex bead array, and SARS-CoV-2-specific T-cell responses were measured by activation-induced marker and intracellular cytokine staining assays. Results. After randomisation (mean 11 months) but prior to COVID-19 vaccination, the BCG group had lower cytokine responses to iSARS stimulation than the Control group. After two doses of ChAdOx1-S, differences in iSARS-induced cytokine responses between the BCG group and Control group were found for three cytokines (CTACK, TRAIL and VEGF). No differences were found between the groups after BNT162b2 vaccination. There were also no differences between the BCG and Control groups in COVID-19 vaccine-induced antigenspecific antibody responses, T-cell activation or T-cell cytokine production. Conclusion. BCG vaccination induced a broad and persistent reduction in ex vivo cytokine responses to SARS-CoV-2. Following COVID-19 vaccination, this effect was abrogated, and BCG vaccination did not influence adaptive immune responses to COVID-19 vaccine antigens. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia / The University of Melbourne. Department of Paediatrics. Parkville, VIC, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | South Australian Health and Medical Research Institute. Precision Medicine Theme. Adelaide, SA, Australia / Flinders University. Flinders Health and Medical Research Institute. Bedford Park, SA, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia. | en_US |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | en_US |
| Affilliation | The University of Sydney. Faculty of Medicine and Health. School of Medical Sciences. Camperdown, NSW, Australia / The University of Sydney. Sydney Institute for Infectious Diseases and the Charles Perkins Centre. Camperdown, NSW, Australia / Centenary Institute. Centre for Infection and Immunity. Camperdown, NSW, Australia. | en_US |
| Affilliation | University of Adelaide. Basil Hetzel Institute for Translational Health Research. Adelaide Medical School. Viral Immunology Group. Adelaide, SA, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia. | en_US |
| Affilliation | Radboud University Medical Center. Department of Internal Medicine and Radboud Institute for Molecular Life Sciences. Nijmegen, The Netherlands / University of Bonn. Life and Medical Sciences Institute. Department for Immunology and Metabolism. Bonn, Germany. | en_US |
| Affilliation | The University of Melbourne. Department of Paediatrics. Parkville, VIC, Australia / Murdoch Children’s Research Institute. Molecular Immunity Group. Infection and Immunity Theme. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Melbourne. Department of Paediatrics. Parkville, VIC, Australia / Murdoch Children’s Research Institute. Population Allergy Group. Parkville, VIC, Australia / The Royal Children’s Hospital Melbourne. Department of Allergy and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia / The University of Melbourne. Department of Paediatrics. Parkville, VIC, Australia / Geneva University Hospitals and Faculty of Medicine. Immunology, Vaccinology, Rheumatology and Infectious Diseases Unit. Geneva, Switzerland. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Melbourne. The Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Parkville, VIC, Australia. | en_US |
| Affilliation | The University of Sydney. Faculty of Medicine and Health. School of Medical Sciences. Camperdown, NSW, Australia / The University of Sydney. Sydney Institute for Infectious Diseases and the Charles Perkins Centre. Camperdown, NSW, Australia / Centenary Institute. Centre for Infection and Immunity. Camperdown, NSW, Australia. | en_US |
| Affilliation | South Australian Health and Medical Research Institute. Precision Medicine Theme. Adelaide, SA, Australia / Flinders University. Flinders Health and Medical Research Institute. Bedford Park, SA, Australia. | en_US |
| Affilliation | Murdoch Children’s Research Institute. Infectious Diseases Group. Infection, Immunity and Global Health Theme. Parkville, VIC, Australia / The University of Melbourne. Department of Paediatrics. Parkville, VIC, Australia / The Royal Children’s Hospital Melbourne. Department of Infectious Diseases. Parkville, VIC, Australia. | en_US |
| Subject | Bacille Calmette–Guerin (BCG) vaccine | en_US |
| Subject | COVID-19 | en_US |
| Subject | Heterologous | en_US |
| Subject | Immunity | en_US |
| Subject | Immunomodulation | en_US |
| e-ISSN | 2050-0068 | |
