| Author | Arêas, Guilherme Peixoto Tinoco | |
| Author | Goulart, Cássia da Luz | |
| Author | Sant’Anna, Thaís | |
| Author | Fernandes, Tiótrefis Gomes | |
| Author | Alvim, Rafael de Oliveira | |
| Author | Borges, Fernanda Facioli dos Reis | |
| Author | Amaral, Camila Miriam Suemi Sato Barros do | |
| Author | Rodrigues, Suzy Cristina França | |
| Author | Valente, Jefferson | |
| Author | Ferreira, João Marcos Bemfica Barbosa | |
| Author | Rezende, Anna Gabriela | |
| Author | Oliveira Júnior, Edival Ferreira de | |
| Author | Lacerda, Marcus Vinícius Guimarães de | |
| Author | Val, Fernando Fonseca de Almeida | |
| Access date | 2025-04-03T19:01:48Z | |
| Available date | 2025-04-03T19:01:48Z | |
| Document date | 2024 | |
| Citation | ARÊAS, Guilherme Peixoto Tinoco et al. Pulmonary Rehabilitation Associated with Noninvasive Ventilation on Physical Capacity and Quality of Life in Post-COVID-19: A Randomized Controlled Double-Blinded Clinical Trial Protocol. Journal of Multidisciplinary Healthcare, v. 17, p. 1483–1490, Apr. 2024. | en_US |
| ISSN | 1178-2390 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69390 | |
| Description | The authors have no conflicts to disclose. | en_US |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
| Language | eng | en_US |
| Publisher | Dove Medical Press | |
| Rights | open access | en_US |
| Title | Pulmonary Rehabilitation Associated with Noninvasive Ventilation on Physical Capacity and Quality of Life in Post-COVID-19: A Randomized Controlled Double-Blinded Clinical Trial Protocol | en_US |
| Type | Article | en_US |
| DOI | 10.2147/JMDH.S438120 | |
| Abstract | Background: The coronavirus disease-2019 (COVID-19) pulmonary rehabilitation (PR) seems to be a better choice to improve physical and functional capacity after acute infection. However, there is a lack of evidence regarding the effects of different strategies to optimize post-acute phase rehabilitation and reduce long COVID-19 physical deteriorations. Objective: To compare the use of a noninvasive ventilation (NIV) plus aerobic exercise strategy during PR program with to a standard PR (without NIV) on physical capacity and quality of life outcomes in post-COVID-19. Methods: Double-blinded randomized controlled clinical trial. A total of 100 individuals discharged from hospital in a post-acute phase of severe COVID-19 will be randomized into two groups: PR + NIV (Group 1) and PR (Group 2). Inclusion criteria include participants who present symptomatic dyspnea II and III by the modified Medical Research Council, aged 18 years or older. Both groups will receive aerobic and resistance exercise, and inspiratory muscle training. However, group 1 will perform aerobic training with bilevel NIV. Cardiopulmonary exercise test will assess the O2 peak uptake, 6-minute walk test will assess the walking distance and short-form 36 will assess the quality of life before and after 8 weeks (after 24 PR sessions). Moreover, patients will be contacted by telephone every 3 months for one year to record possible adverse events, hospitalizations, and death. All data will be registered in RedCap, and analyses will be performed in the STATA v13 software. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade do Estado do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brasil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | Noninvasive ventilation | en_US |
| Subject | Pulmonary rehabilitation | en_US |
