| Author | Souza, Ramon Andrade de | |
| Author | Barreto, Florisneide Rodrigues | |
| Author | Lima, Carla Cristina Oliveira de Jesus | |
| Author | Natividade, Marcio Santos da | |
| Author | Santos, Carlos Antônio de Souza Teles | |
| Author | Ichihara, Maria Yury | |
| Author | Pereira, Marcos | |
| Author | Castro, Daniel Barros de | |
| Author | Genser, Bernd | |
| Author | Rodrigues, Laura Cunha | |
| Author | Barreto, Maurício Lima | |
| Author | Pereira, Susan Martins | |
| Access date | 2025-04-04T15:13:57Z | |
| Available date | 2025-04-04T15:13:57Z | |
| Document date | 2025 | |
| Citation | SOUZA, R. A. de et al. Efficacy of BCG vaccination on incidence, severity and clinical progression of COVID-19: A BCG-REVAC population analysis. Vaccine, v. 54, p. 1-6, 2025. | en_US |
| ISSN | 1873-2518 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69414 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Ministério da Ciência, Tecnologia e Inovações (MCTI). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Title | Efficacy of BCG vaccination on incidence, severity and clinical progression of COVID-19: A BCG-REVAC population analysis | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.vaccine.2025.126911 | |
| Abstract | Background: Can vaccination with Bacille Calmette-Guérin prevent clinical progression of COVID-19? Data from the BCG-REVAC trial was archived in a database, creating an excellent opportunity to link it to notified cases of COVID-19 to evaluate the efficacy of BCG against incidence, severity and clinical progression to severe COVID-19 when given at birth day, at school age as a first dose or as a second dose. Methods: This study was conducted in the population of the BCG-REVAC cluster randomisation trial including 354,403 schoolchildren, aged 7 to 14 years, from 767 schools from two cities, Salvador and Manaus. Cases of COVID-19 from the System for Notification of Infectious Diseases and the System for Notification of Severe Respiratory Illnesses were record linked to BCG-REVAC population. The exposure was Vaccination or revaccination obtained by the BCG-REVAC. The outcomes of interest in this study were incidence COVID-19; incidence of severe COVID-19; and clinical progression of COVID-19. This project was approved by the Ethics Committee of the Institute of Collective Health, Federal University of Bahia, Brazil. Results: The neonatal dose and a first dose of BCG at school age protect against the incidence of severe COVID-19 in multivariate models, whose efficacies were 30 % (95 %CI:1–51) and 64 % (95 %CI: 22–84), respectively. The neonatal dose showed an effect on severe clinical progression of symptomatic COVID-19 disease in COVID-19 infected subjects 39 % (95 %CI:11 % - 58 %). Conclusion: Even 23 years after BCG vaccination and revaccination of school-age children our results suggesting a protective effect of BCG first dose against incidence of severe COVID-19 in infected individuals, a smaller effect of the neonatal dose and no effect of the second dose at school age. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / High5Data Ltd. Heidelberg, Germany. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Faculty of Epidemiology. London School of Hygiene and Tropical Medicine. London, UK. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
| Subject | BCG | en_US |
| Subject | Bacillus Calmette-Guérin | en_US |
| Subject | Efficacy | en_US |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV -2 | en_US |
| Subject | Severity | en_US |
| Subject | Vaccination | en_US |
| DeCS | Mycobacterium bovis | en_US |
| DeCS | Vacina BCG | en_US |
| DeCS | Eficácia | en_US |
| DeCS | COVID-19 | en_US |
| DeCS | Coronavírus Relacionado à Síndrome Respiratória Aguda Grave | en_US |
| DeCS | Vacinação | en_US |
| Embargo date | 2026 | |
