| Author | Almeida, Glaucia M. | |
| Author | Silva, Bruna M. | |
| Author | Arruda, Eurico | |
| Author | Sebollela, Adriano | |
| Access date | 2025-04-14T13:00:28Z | |
| Available date | 2025-04-14T13:00:28Z | |
| Document date | 2025 | |
| Citation | ALMEIDA, Glaucia M.; SILVA, Bruna M.; ARRUDA, Eurico; SEBOLLELA, Adriano. Human brain tissue cultures: a unique ex vivo model to unravel the pathogenesis of neurotropic arboviruses. Current Opinion in Virology, v. 70, p. 101453, 2025. | en_US |
| ISSN | 1879-6265 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69616 | |
| Description | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. | en_US |
| Sponsorship | This work was supported by The São Paulo Research Foundation (FAPESP) (Grants: #2021/10925-8; #2019/26119-0), Research and Assistance Supporting Foundation of the Hospital das Clínicas of the Ribeirão Preto Medical School (FAEPA), Brasil, National Council for Scientific and Technological Development (CNPq), Brasil, and Federal Agency for Suport and Evaluation of Graduate Education (CAPES), Brasil. GMA received a scholarship from FAPESP (#2021/12263-2). AS and EA are recipients of CNPq scientific productivity fellowships. | en_US |
| Language | por | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Title | Human brain tissue cultures: a unique ex vivo model to unravel the pathogenesis of neurotropic arboviruses | en_US |
| Type | Article | |
| Abstract | Arboviruses are transmitted by arthropods, and their spread from endemic to nonendemic regions has been accelerated by deforestation, climate change, and global mobility. Arbovirus infection in human results in symptoms ranging from mild to life threatening, with the impairment of central nervous system functions being reported in severe cases. Despite its clinical relevance, the mechanisms by which arboviruses led to neural dysfunction are still poorly understood. The lack of a widespread human central nervous system model to study the virus–host interaction challenges the advance of our knowledge on these mechanisms. In this context, human brain-derived ex vivo models have the advantage of preserving cellular diversity, cell connections, and tissue cytoarchitecture found in human brain, raising them as a powerful strategy to elucidate the cellular- molecular alterations underlying brain diseases. Here, we review recent advances in the field of neurotropic arboviruses obtained using ex vivo human brain tissue as the experimental model. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Virologia. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Ribeirão Preto, SP, Brasil / Fundação Oswaldo Cruz. Presidência. Plataforma de Pesquisa em Medicina Translacional. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Virologia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | en_US |
| Subject | Arboviruses | en_US |
| Subject | Neurotropism | en_US |
| Subject | Ex vivo models | en_US |
| Subject | Human brain tissue culture | en_US |
| Subject | Pathogenesis | en_US |
| Subject | Viral infection | en_US |
| Subject | Microglia | en_US |
| Subject | Neurovirulence | en_US |
| Subject | Oropouche | en_US |
| Subject | Zika | en_US |
| Subject | Encephalitis | en_US |
| DeCS | Arboviruses | en_US |
| DeCS | Homeopathic Pathogenesy | en_US |
| DeCS | Virus Diseases | en_US |
| DeCS | Microglia | en_US |
| DeCS | Bunyaviridae Infections | en_US |
| DeCS | Zika Virus Infection | en_US |
| DeCS | Infectious Encephalitis | en_US |
