| Author | Santos, Juliana da Costa | |
| Author | Reis Junior, Paulo Sergio dos | |
| Author | Luz, Adriana Gomes | |
| Author | Cecatti, Jose Guilherme | |
| Author | Souza, Renato T. | |
| Author | Tedesco, Ricardo P. | |
| Author | Fernandes, Karayna G. | |
| Author | Costa, Sérgio H. A. Martins | |
| Author | Peret, Frederico J. A. | |
| Author | Feitosa, Francisco E. | |
| Author | Traina, Evelyn | |
| Author | Cunha Filho, Edson V. | |
| Author | Vettorazzi, Janete | |
| Author | Haddad, Samira M. | |
| Author | Andreucci, Carla B. | |
| Author | Guida, José P. | |
| Author | Correa Junior, Mario D. | |
| Author | Dias, Marcos A. B. | |
| Author | Oliveira, Leandro G. | |
| Author | Melo Junior, Elias F. | |
| Author | Luz, Marília G. Q. da | |
| Author | Costa, Maria Laura | |
| Access date | 2025-04-17T00:51:23Z | |
| Available date | 2025-04-17T00:51:23Z | |
| Document date | 2025 | |
| Citation | SANTOS, J. C. et al. Adverse perinatal outcomes of unvaccinated pregnant women with respiratory symptoms during the COVID-19 pandemic: Evidence from a Brazilian multicenter study. International Journal of Gynecological Obstetrical , Online ahead of print, 2025. | en_US |
| ISSN | 1879-3479 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69711 | |
| Language | eng | en_US |
| Publisher | International Federation of Gynecology and Obstetrics | en_US |
| Rights | open access | en_US |
| MeSH | Unvaccinated Persons | en_US |
| MeSH | Pregnancy | en_US |
| MeSH | COVID-19 | en_US |
| MeSH | Signs and Symptoms Respiratory | en_US |
| MeSH | Brazil | en_US |
| MeSH | Multicenter Study | en_US |
| MeSH | Perinatal Care | en_US |
| Title | Adverse perinatal outcomes of unvaccinated pregnant women with respiratory symptoms during the COVID-19 pandemic: Evidence from a Brazilian multicenter study | en_US |
| Type | Article | en_US |
| Abstract | Objective: The current study aimed to describe risk factors for adverse perinatal outcomes (APOs) among pregnant women nonvaccinated for COVID-19 who had respiratory symptoms.
Methods: A nested case–control study was performed within the REBRACO (in
Portuguese, the Brazilian Network of COVID-19 During Pregnancy) initiative. Women
were recruited during pregnancy in 15 maternity hospitals in Brazil from February 1,
2020, to February 28, 2021, while seeking medical care for respiratory symptoms,
and were followed up until childbirth regardless of confirmation of COVID-19. For this
analysis, women were divided into two groups: (1) those with APOs, defined as the
occurrence of fetal or neonatal death, preterm delivery, 5-min Apgar score <7, neonatal respiratory distress, neonatal mechanical ventilation, admission to the neonatal
intensive care unit, small-for-gestational-age newborn, or any neonatal morbidity; and
(2) those without APOs.
Results: The total number of women included in this analysis was 481, with 210 having APOs (43.7%). The characteristics independently associated with APOs were a
composite outcome of severe acute respiratory syndrome, maternal admission at the
intensive care unit, or maternal death (relative risk [RR], 3.30 [95% confidence interval
(CI), 1.38–7.89]), living in the North and Northeastern regions of Brazil (RR, 3.09 [95%
CI, 1.13–8.41]), and pre-eclampsia (RR, 2.77 [95% CI, 1.19–6.43]). Conclusion: Severe maternal illness was strongly associated with APO regardless of
COVID-19 confirmation. It is essential to provide sufficient and timely health care for
women who have respiratory symptoms compatible with COVID-19. | en_US |
| Affilliation | University of Campinas. Department of Obstetrics and Gynecology | en_US |
| Affilliation | Jundiaí School of Medicine—HU/FMJ | en_US |
| Affilliation | Clinics Hospital of Porto Alegre | en_US |
| Affilliation | UNIMED Maternity—UNIMED/BH | en_US |
| Affilliation | Federal University of Ceará—MEAC/UF | en_US |
| Affilliation | Federal University of São Paulo— UNIFESP/EPM | en_US |
| Affilliation | 7 Moinhos de Vento Hospital—HMV | en_US |
| Affilliation | Jorge Rossmann Regional Hospital— Sócrates Guanaes Institute | en_US |
| Affilliation | Federal University of São Carlos/ UFSCAR | en_US |
| Affilliation | Sumaré State Hospital—HES | en_US |
| Affilliation | Federal University of Minas Gerais—HC/ UFMG | en_US |
| Affilliation | Fernandes Figueira Institute—IFF/ Fiocruz | en_US |
| Affilliation | São Paulo State University School of Medicine | en_US |
| DeCS | Pessoas não Vacinadas | en_US |
| DeCS | Gravidez | en_US |
| DeCS | COVID-19 | en_US |
| DeCS | Sinais e Sintomas Respiratórios | en_US |
| DeCS | Brasil | en_US |
| DeCS | Estudo Multicêntrico | en_US |
| DeCS | Assistência Perinatal | en_US |
