| Author | Sonon, Paulin | |
| Author | Brito Ferreira, Maria Lúcia | |
| Author | Santos Almeida, Renata | |
| Author | Saloum Deghaide, Neifi Hassan | |
| Author | Henrique Willcox, Glauco | |
| Author | Guimarães, Elizabeth Lima | |
| Author | da Purificação Júnior, Antônio Fernando | |
| Author | Cordeiro, Marli Tenório | |
| Author | Antunes de Brito, Carlos Alexandre | |
| Author | de Albuquerque, Maria de Fátima Militão | |
| Author | Lins, Roberto D | |
| Author | Donadi, Eduardo A | |
| Author | Lucena-Silva, Norma | |
| Access date | 2025-04-24T00:07:10Z | |
| Available date | 2025-04-24T00:07:10Z | |
| Document date | 2021 | |
| Citation | SONON, Paulin et al. Differential Frequencies of HLA-DRB1, DQA1, and DQB1 Alleles and Haplotypes are Observed in the ArbovirusRelated Neurological Syndromes. The Journal of Infectious Diseases, v. 224, n. 3, p. 517-525, Aug. 2021. | en_US |
| ISSN | 0022-1899 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69826 | |
| Sponsorship | This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; grant numbers 440760/2016-0 and 302060/2019-7); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (grant number 88881.130769/2016-01); and the Aggeu Magalhães Institute/Fundação Oswaldo Cruz. P. S. was supported by Fundação Oswaldo Cruz (grant number INOVA FIOCRUZ/02/2019 PDJ); N. L.-S. and R. D. L. are CNPq scholarship holders (grant numbers 310364/2015-9 and 310892/2019-8); and A. F. P. J. was sponsored by Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco. Computer allocation was provided by Laboratório Nacional de Computação Científica. | en_US |
| Language | eng | en_US |
| Publisher | Oxford | en_US |
| Rights | open access | en_US |
| Title | Differential Frequencies of HLA-DRB1, DQA1, and DQB1 Alleles and Haplotypes are Observed in the ArbovirusRelated Neurological Syndromes | en_US |
| Type | Article | en_US |
| DOI | 10.1093/infdis/jiaa764 | |
| Abstract | Background: We took advantage of the 2015-2016 Brazilian arbovirus outbreak (Zika [ZIKV]/dengue/chikungunya viruses) associated with neurological complications to type HLA-DRB1/DQA1/DQB1 variants in patients exhibiting neurological complications and in bone marrow donors from the same endemic geographical region. Methods: DRB1/DQA1/DQB1 loci were typed using sequence-specific oligonucleotides. In silico studies were performed using X-ray resolved dimer constructions. Results: The DQA1*01, DQA1*05, DQB1*02, or DQB1*06 genotypes/haplotypes and DQA1/DQB1 haplotypes that encode the putative DQA1/DQB1 dimers were overrepresented in the whole group of patients and in patients exhibiting peripheral neurological spectrum disorders (PSD) or encephalitis spectrum disorders (ESD). The DRB1*04, DRB1*13, and DQA1*03 allele groups protected against arbovirus neurological manifestation, being underrepresented in whole group of patients and ESD and PSD groups. Genetic and in silico studies revealed that DQA1/DQB1 dimers (1) were primarily associated with susceptibility to arbovirus infections; (2) can bind to a broad range of ZIKV peptides (235 of 1878 peptides, primarily prM and NS2A); and (3) exhibited hydrophilic and highly positively charged grooves when compared to the DRA1/DRB1 cleft. The protective dimer (DRA1/DRB1*04) bound a limited number of ZIKV peptides (40 of 1878 peptides, primarily prM).
Conclusion: Protective haplotypes may recognize arbovirus peptides more specifically than susceptible haplotypes. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Immunology Department. Recife, PE, Brazil. | en_US |
| Affilliation | Hospital da Restauração Governador Paulo Guerra. Recife, PE, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Immunology Department. Recife, PE, Brazil. | en_US |
| Affilliation | University of Sao Paulo. Ribeirão Preto Medical School. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Laboratório HLA Diagnóstico. Recife, PE, Brasil. | en_US |
| Affilliation | Laboratório HLA Diagnóstico. Recife, PE, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Virology Department. Recife, PE, Brazil. | en_US |
| Affilliation | Federal University of Pernambuco. Internal Medicine Department. Recife, PE, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Public Health Department. Recife, PE, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Virology Department. Recife, PE, Brazil. | en_US |
| Affilliation | University of Sao Paulo. Ribeirão Preto Medical School. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Immunology Department. Recife, PE, Brazil. | en_US |
| Subject | HLA-DRB1 | en_US |
| Subject | HLA-DQA1 | en_US |
| Subject | HLA-DQB1 | en_US |
| Subject | ZIKV | en_US |
| Subject | DENV | en_US |
| Subject | CHIKV | en_US |
| Subject | Brazil | en_US |
| e-ISSN | 1537-6613 | |
