| Author | Silva Filho, João da | |
| Author | Herder, Vanessa | |
| Author | Gibbins, Matthew P. | |
| Author | Reis, Monique Freire dos | |
| Author | Melo, Gisely Cardoso | |
| Author | Haley, Michael J. | |
| Author | Judice, Carla Cristina | |
| Author | Val, Fernando Fonseca Almeida | |
| Author | Borba, Mayla | |
| Author | Tavella, Tatyana Almeida | |
| Author | Sampaio, Vanderson de Sousa | |
| Author | Attipa, Charalampos | |
| Author | McMonagle, Fiona | |
| Author | Wright, Derek | |
| Author | Lacerda, Marcus Vinicius Guimaraes de | |
| Author | Costa, Fabio Trindade Maranhão | |
| Author | Couper, Kevin N. | |
| Author | Monteiro, Wuelton Marcelo | |
| Author | Ferreira, Luiz Carlos de Lima | |
| Author | Moxon, Christopher Alan | |
| Author | Palmarini, Massimo | |
| Author | Marti, Matthias | |
| Access date | 2025-04-30T14:06:04Z | |
| Available date | 2025-04-30T14:06:04Z | |
| Document date | 2024-09 | |
| Citation | SILVA FILHO, João da; HERDER, Vanessa; GIBBINS, Matthew P.; REIS, Monique Freire dos; MELO, Gisely Cardoso; HALEY, Michael J.; JUDICE, Carla Cristina; VAL, Fernando Fonseca Almeida; BORBA, Mayla; TRAVELLA, Tatyana Almeida; SAMPAIO, Vanderson de Sousa; ATTIPA, Charalampos; MCMONAGLE, Fiona; WRIGHT, Derek; LACERDA, Marcus Vinicius Guimaraes de et al. A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, v. 16, sep. 2024. | en_US |
| ISSN | 1946-6242 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/70039 | |
| Language | eng | en_US |
| Rights | open access | en_US |
| Title | A spatially resolved single- cell lung atlas integrated with clinical and blood signatures distinguishes COVID- 19 disease trajectories | en_US |
| Type | Article | en_US |
| Abstract | COVID-19 is characterized by a broad range of symptoms and disease trajectories. Understanding the correlation between clinical biomarkers and lung pathology during acute COVID-19 is necessary to understand its diverse pathogenesis and inform more effective treatments. Here, we present an integrated analysis of longitudinal clinical parameters, peripheral blood markers, and lung pathology in 142 Brazilian patients hospitalized with COVID-19.
We identified core clinical and peripheral blood signatures differentiating disease progression between patients who recovered from severe disease compared with those who succumbed to the disease. Signatures were heterogeneous among fatal cases yet clustered into two patient groups: “early death” (<15 days until death) and “late death” (>15 days). Progression to early death was characterized systemically and in lung histopathological samples by rapid endothelial and myeloid activation and the presence of thrombi associated with SARS-CoV-2+macrophages. In contrast, progression to late death was associated with fibrosis, apoptosis, and SARS-CoV-2+epithelial cells in postmortem lung tissue. In late death cases, cytotoxicity, interferon, and T helper 17 (TH17) signatures were only detectable in the peripheral blood after 2 weeks of hospitalization. Progression to recovery was associated with higher lymphocyte counts, TH2 responses, and anti-inflammatory–mediated responses. By integrating antemortem longitudinal blood signatures and spatial single-cell lung signatures from postmortem lung samples, we defined clinical parameters that could be used to help predict COVID-19 outcomes. | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | Institute of Parasitology Zurich (IPZ), VetSuisse Faculty, University of Zurich, Zurich, Switzerland | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | Universidade Federal do Amazonas, Manaus, AM, Brasil | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil | en_US |
| Affilliation | Department of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester, Manchester, UK | en_US |
| Affilliation | Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brasil | en_US |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil | en_US |
| Affilliation | Delphina Rinaldi Abdel Aziz Emergency Hospital (HPSDRA ), Manaus, Brasil | en_US |
| Affilliation | Universidade Federal do Amazonas, Manaus, AM, Brasil | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | MRC -University of Glasgow Centre for Virus Research, Glasgow, UK | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Leônidas & Maria Deane, Manaus, AM, Brasil | en_US |
| Affilliation | Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brasil | en_US |
| Affilliation | Department of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester, Manchester, UK | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Affilliation | MRC -University of Glasgow Centre for Virus Research, Glasgow, UK | en_US |
| Affilliation | Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK | en_US |
| Subject | COVID-19 | en_US |
| DeCS | COVID-19 | en_US |
