| Autor | Cunha, Danton Machado da | |
| Autor | Mediano, Mauro Felippe Felix | |
| Autor | Rimolo, Lorena dos Santos Marreto | |
| Autor | Costa, Andrea Rodrigues da | |
| Autor | Diogo, Danilo Bento | |
| Autor | Sangenis, Luiz Henrique Conde | |
| Autor | Veloso, Henrique Horta | |
| Autor | Holanda, Marcelo Teixeira de | |
| Autor | Hasslocher-Moreno, Alejandro Marcel | |
| Autor | Cunha, Ademir Batista da | |
| Autor | Saraiva, Roberto Magalhães | |
| Data de acesso | 2025-05-03T00:28:55Z | |
| Data de disponibilização | 2025-05-03T00:28:55Z | |
| Data do publicação | 2025 | |
| Citação | CUNHA, Danton Machado da et al. Predictors of Incident Heart Failure in Patients With Chronic Chagas Disease Cardiomyopathy. Echocardiography, v. 42, p. 1-9, Mar. 2025. | en_US |
| ISSN | 0742-2822 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/70075 | |
| Fomento | This research was supported by the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Brazil [grant numbers E-26/201.561/2014 and E-26/110.176/2014], and Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (grant numbers 407655/2012-3, 421843/2017-9, and 305088/2013-0). | en_US |
| Idioma | eng | en_US |
| Editor | Wiley Periodicals | en_US |
| Direito Autoral | open access | en_US |
| Título | Predictors of Incident Heart Failure in Patients With Chronic Chagas Disease Cardiomyopathy | en_US |
| Tipo do documento | Article | en_US |
| DOI | 10.1111/echo.70163 | |
| Resumo em Inglês | Purpose: Patients with chronic Chagas cardiomyopathy (CCC) have a high mortality due to heart failure (HF). The aim of this study was to investigate clinical and echocardiographic predictors of incident HF in patients with CCC. Methods: Single-center retrospective longitudinal observational study which included 176 adult patients (59.1% women; 53.9 ± 10 years old; mean left ventricular [LV] ejection fraction 62% ± 10%) at an early stage of CCC (electrocardiogram and/or wall motion changes but no HF). The primary outcome was incident HF. The association between studied parameters with incident HF was performed by competing-risk survival regression models using the Fine and Gray method. Results: After a mean follow-up of 8.8 ± 3.6 years, 42 patients progressed to HF (27.04 cases/1000 patient-years). A
model 0 adjusted for clinical and 2D-Doppler echocardiographic parameters and for all-cause mortality revealed diabetes mellitus (HR 4.91, 95% CI 1.67–14.4, p = 0.004), LV ejection fraction (HR 0.96, 95% CI 0.93–0.99, p = 0.022), and E’ velocity (HR 0.79, 95% CI 0.67–0.95, p = 0.01) as independently associated with incident HF. The addition of strain-derived parameters to model 0 revealed that LV global circumferential strain (HR 0.83, 95% CI 0.78–0.89, p < 0.001) and left atrial booster contraction strain (HR 1.14, 95% CI 1.02–1.28, p = 0.022) were associated with incident HF. Conclusion: While most clinical parameters were not associated with incident HF in patients with CCC, echocardiographic parameters, including LV systolic and diastolic function and strain-derived parameters, were associated with incident HF in patients with CCC. This knowledge can be very useful for planning the care and follow-up of these patients. | en_US |
| Afiliação | Fluminense Federal University. Antonio Pedro University Hospital. Niterói, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Fluminense Federal University. Antonio Pedro University Hospital. Niterói, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Afiliação | Fluminense Federal University. Antonio Pedro University Hospital. Niterói, RJ, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil. | en_US |
| Palavras-chave em inglês | Chronic Chagas cardiomyopathy | en_US |
| Palavras-chave em inglês | Chagas disease | en_US |
| Palavras-chave em inglês | Heart failure | en_US |
| Palavras-chave em inglês | Patients with CCC | en_US |
| e-ISSN | 1540-8175 | |
