Author | Garcia-Oliveira, Gabriela Fernanda | |
Author | Biccas, Mikaelly Frasson | |
Author | Jacob, Daniel | |
Author | Oliveira, Marcelle Alves | |
Author | Paschoal, Ana Maria de Oliveira | |
Author | Alves, Pedro Augusto | |
Author | Barreto, Cecilia | |
Author | Vilela, Daniel Ambrosio da Rocha | |
Author | Teixeira, Érika Procópio Tostes | |
Author | Stehling, Thiago Lima | |
Author | Mendes, Thais Melo | |
Author | Silva, Marlise Costa | |
Author | Almeida, Munique Guimarães | |
Author | Sonoda, Ivan Vieira | |
Author | Mello, Érica Munhoz | |
Author | Gama, Francisco Elias Nogueira | |
Author | Hanley, Kathryn A. | |
Author | Vasilakis, Nikos | |
Author | Drumond, Betania Paiva | |
Access date | 2025-05-07T14:07:34Z | |
Available date | 2025-05-07T14:07:34Z | |
Document date | 2025 | |
Citation | OLIVEIRA, Gabriela Fernanda Garcia et al. Human herpesvirus 1 associated with epizootics in Belo Horizonte, Minas Gerais, Brazil. Viruses, v. 17, n. 5, 660, 2025. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/70260 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Human herpesvirus 1 associated with epizootics in Belo Horizonte, Minas Gerais, Brazil. | en_US |
Type | Article | en_US |
DOI | 10.3390/v17050660 | |
Abstract | Human activity in sylvatic environments and resulting contact with wildlife, such as non-human primates (NHPs), can lead to pathogen spillover or spillback. Both NHPs and humans host a variety of herpesviruses. While these viruses typically cause asymptomatic infections in their natural hosts, they can lead to severe disease or even death when they move into novel hosts. In early 2024, deaths of Callithrix penicillata, the black-tufted marmoset, were reported in an urban park in Belo Horizonte, Minas Gerais, Brazil. The epizootic was investigated in collaboration with CETAS/IBAMA and the Zoonoses Department of Belo Horizonte. Nine marmoset carcasses and four sick marmosets were found in the park; the latter exhibited severe neurological symptoms and systemic illness before succumbing within 48 h. Carcasses were tested for rabies virus and were all negative, and necropsy findings revealed widespread organ damage. In addition, the samples were tested for yellow fever virus, with negative results. Finally, molecular testing, viral isolation, and phylogenetic analysis demonstrated human herpesvirus 1 (HHV-1) as the causative agent. The likely source of infection was human-to-marmoset transmission, facilitated by close interactions such as feeding and handling. This study highlights the risks of pathogen spillover between humans and nonhuman primates, emphasizing the need for enhanced surveillance and public awareness to mitigate future epizootics. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais não Renováveis. Centro de Triagem de Animais Silvestres. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais não Renováveis. Centro de Triagem de Animais Silvestres. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Estado de Minas Gerais. Instituto Estadual de Florestas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Estado de Minas Gerais. Instituto Estadual de Florestas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Diretoria de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Laboratório de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Laboratório de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Laboratório de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Centro de Controle de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Prefeitura de Belo Horizonte. Laboratório de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Department of Biology. New Mexico State University. Las Cruces, USA. | en_US |
Affilliation | Department of Pathology. University of Texas Medical Branch.Galveston, TX, USA. / Center for Vector-Borne and Zoonotic Diseases. The University of Texas Medical Branch. Galveston, TX, USA. / Institute for Human Infection and Immunity. University of Texas Medical Branch. Galveston, TX, USA. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departament de Microbiologia. Laboratório de Virus. Belo Horizonte, MG, Brasil. | en_US |
Subject | Human herpesvirus 1 (HHV-1) | en_US |
Subject | Zoonotic transmission | en_US |
Subject | Spillback | en_US |
Subject | Non-human primates | en_US |
Subject | Cross-species infection | en_US |
Subject | Sylvatic environments | en_US |
Subject | Urban wildlife disease | en_US |
Subject | Wildlife disease surveillance | en_US |