| Author | Ceccarelli, Giancarlo | |
| Author | Branda, Francesco | |
| Author | Scarpa, Fabio | |
| Author | Ciccozzi, Massimo | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Giovanetti, Marta | |
| Access date | 2025-05-07T14:58:11Z | |
| Available date | 2025-05-07T14:58:11Z | |
| Document date | 2025 | |
| Citation | CECCARELLI, Giancarlo et al. Oropouche virus infection: differential clinical outcomes and emerging global concerns of vertical transmission and fatal cases. International Journal of Infectious Diseases, v. 150, n. 107295, p. 1-2, Jan. 2025. | |
| ISSN | 1201-9712 | |
| URI | https://www.arca.fiocruz.br/handle/icict/70263 | |
| Description | Produção científica do Laboratório de Arbovírus e Vírus Hemorrágicos. | pt_BR |
| Sponsorship | Not applicable. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | open access | |
| Title | Oropouche virus infection: differential clinical outcomes and emerging global concerns of vertical transmission and fatal cases | en_US |
| Type | Letter | |
| DOI | 10.1016/j.ijid.2024.107295 | |
| Abstract | Oropouche virus (OROV), a member of the Peribunyaviridae family, has emerged as a significant arboviral threat, particularly in South and Central America. Traditionally causing mild febrile illness, recent outbreaks have revealed severe clinical outcomes, including aseptic meningitis, encephalitis, and, more recently, vertical transmission leading to congenital anomalies and fatalities. Environmental changes, including deforestation and climate shifts, have expanded the virus's geographic range, as seen in Brazil, where over 8000 cases were reported by August 2024, compared to fewer than 831 in 2023. For the first time, vertical transmission has been confirmed, with cases of fetal deaths and congenital anomalies such as microcephaly and agenesis of the corpus callosum, drawing parallels to the Zika virus outbreak in 2015-2016. Despite these alarming trends, key mechanisms of placental transmission, maternal immunity, and fetal susceptibility remain poorly understood. This perspective highlights the urgent need for a coordinated global response, focusing on enhanced surveillance in newly affected regions, vector control strategies, and research into the factors driving severe clinical outcomes. Strengthening global efforts will be crucial in mitigating the public health threat posed by OROV, particularly in light of its potential for further geographic expansion and severe clinical manifestations. | en_US |
| Affilliation | University of Rome Sapienza. Department of Public Health and Infectious Diseases. Rome, Italy / Azienda Ospedaliero Universitaria Umberto I. Rome, Italy / Migrant and Global Health Research Organization. Rome, Italy. | |
| Affilliation | University Campus Bio-Medico. Medical Statistics and Molecular Epidemiology. Rome, Italy. | |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. | |
| Affilliation | University Campus Bio-Medico. Medical Statistics and Molecular Epidemiology. Rome, Italy. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Università Campus Bio-Medico di Roma. Sciences and Technologies for Sustainable Development and One Health. Roma, Italy / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | |
| Subject | Oropouche | en_US |
| Subject | Differential clinical outcomes | en_US |
| Subject | Global concerns | en_US |
| Subject | Vertical transmission | en_US |
| Subject | Fatal cases | en_US |
| DeCS | Infecções por Bunyaviridae | pt_BR |
| DeCS | Transmissão Vertical de Doenças Infecciosas | pt_BR |
| DeCS | Anormalidades Congênitas | pt_BR |
| DeCS | Vigilância em Saúde Pública | pt_BR |
| e-ISSN | 1878-3511 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
| xmlui.metadata.dc.subject.ods | 13 Ação contra a mudança global do clima | |
