| Author | Trugilho, Liana | |
| Author | Alvarenga, Lívia | |
| Author | Cardozo, Ludmila | |
| Author | Paiva, Bruna | |
| Author | Brito, Jessyca | |
| Author | Barboza, Isis | |
| Author | Almeida, Jonatas | |
| Author | Anjos, Juliana dos | |
| Author | Khosla, Pramod | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Mafra, Denise | |
| Access date | 2025-05-14T01:55:41Z | |
| Available date | 2025-05-14T01:55:41Z | |
| Document date | 2025 | |
| Citation | TRUGILHO, Liana et al. Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial. Journal of Nutrition and Metabolism, v. 2025, p. 1-15, Jan. 2025. | en_US |
| ISSN | 2090-0724 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/70392 | |
| Language | eng | en_US |
| Publisher | Wiley | en_US |
| Rights | open access | en_US |
| Title | Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial | en_US |
| Type | Article | en_US |
| DOI | 10.1155/jnme/8482883 | |
| Abstract | Tocotrienols, isomers of vitamin E, may provide an effective nutritional strategy to mitigate common cardiovascular risks such as dyslipidemia, inflammation, and oxidative stress in patients with chronic kidney disease (CKD). This double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effects of a tocotrienol-rich fraction (TRF) supplementation (300 mg/day) on oxidative stress and inflammatory markers, including transcription factors in nondialysis (ND) and hemodialysis (HD) CKD patients for three months. Interleukin-6, tumor necrosis factor-α (IL-6 and TNF-α), C-reactive protein (CRP), lipid peroxidation, biochemical parameters, and transcription factors such as NRF2 and NF-κB mRNA expression were evaluated. Seventeen HD patients (9 in the placebo group, 8 in the TRF group) and 16 ND CKD patients (8 in the placebo group and 8 in the TRF group) completed the study. In HD patients, significant reductions were observed in LDL cholesterol (p=0.04) and total plasma cholesterol levels (p=0.01) after TRF intervention. CRP serum levels decreased significantly in ND CKD patients (p=0.05) after TRF supplementation. Transcription factors NRF2 and NF-κB mRNA expressions remained unaltered in both groups. This study suggests that TRF supplementation may mitigate dyslipidemia and inflammation, factors involved with increased cardiovascular risk, in CKD patients, with variations in efficacy between HD and ND patients. Trial Registration: ClinicalTrials.gov identifier: NCT04900532. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Physiology-Graduate Program in Biological Sciences. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Physiology-Graduate Program in Biological Sciences. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Clinic Unit of Research. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Wayne State University. Department of Nutrition and Food Science. Detroit, Michigan, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Physiology-Graduate Program in Biological Sciences. Rio de Janeiro, RJ, Brazil / Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil. | en_US |
| Subject | Chronic kidney disease | en_US |
| Subject | Dyslipidemia | en_US |
| Subject | Infammation | en_US |
| Subject | NF-κB | en_US |
| Subject | NRF2 | en_US |
| Subject | Oxidative stress | en_US |
| Subject | Tocotrienol | en_US |
| e-ISSN | 2090-0732 | |
