| Author | Kemp, Julie Ann | |
| Author | Fanton, Susane | |
| Author | Baptista, Beatriz G. | |
| Author | Ribeiro, Marcia | |
| Author | Cardozo, Ludmila F. M. F. | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Mafra, Denise | |
| Access date | 2025-05-21T23:55:54Z | |
| Available date | 2025-05-21T23:55:54Z | |
| Document date | 2025 | |
| Citation | KEMP, Julie Ann et al. Short Report: Influence of Dark Chocolate Intake on Magnesium Status in Hemodialysis Patients. Journal of Renal Nutrition, p. 1-5, Feb. 2025. | en_US |
| ISSN | 1051-2276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/70537 | |
| Sponsorship | Financial Disclosure: The authors declare that they have no relevant financial interests. | en_US |
| Language | eng | en_US |
| Publisher | Saunders | en_US |
| Rights | restricted access | en_US |
| Title | Short Report: Influence of Dark Chocolate Intake on Magnesium Status in Hemodialysis Patients | en_US |
| Type | Article | en_US |
| DOI | 10.1053/j.jrn.2025.02.002 | |
| Abstract | Objective: Magnesium (Mg2+) deficiency can be observed in patients with chronic kidney disease (CKD) and is associated with increased inflammation, disease progression, and mortality. Dark chocolate is an excellent source of Mg2+. This study aimed to evaluate the effect of 70% cocoa chocolate intake on Mg2+ serum levels in patients with CKD on hemodialysis (HD). Methods: These are secondary analyses from a previous controlled pilot study. The study included 59 patients undergoing HD. Patients were allocated into 2 groups: dark chocolate and the control group. The dark chocolate group received 40 g of 70% cocoa chocolate for 2 months during HD sessions (3 times a week). The control group did not receive any intervention. Mg2+ was evaluated by a colorimetric test using a commercial kit (Bioclin®). NCT04600258 on March 1, 2020, retrospectively registered. Results: Thirty-five patients in the dark chocolate group (17 women, 53.4 ± 12.9 years) and 11 in the control group (4 women, 46.7 ± 10.9 years) completed the study. The median (interquartile range) overall Mg2+ serum levels were 2.4 (0.4) mg/dL, with no significant differences between the groups. After 2 months of supplementation, serum levels of Mg2+ increased significantly in the dark chocolate group from 2.5 (2.4-2.6) to 2.7 (2.6-2.8) mg/dL (P < .01). No change was observed in potassium and phosphorus plasma levels. Conclusions: Dark chocolate might be a promising nutritional strategy to improve Mg2+ levels in patients with CKD on HD. The offered dose was safe, not altering plasma phosphorus and potassium levels. | en_US |
| Affilliation | Fluminense Federal University. Post-Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Post-Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Post-Graduate Program in Medical Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Graduate Program in Biological Sciences - Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Post-Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fluminense Federal University. Post-Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Medical Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Graduate Program in Biological Sciences - Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Chronic kidney disease | en_US |
| Subject | Hemodialysis | en_US |
| Subject | Magnesium | en_US |
| Subject | Ddark chocolate | en_US |
| Subject | Bioactive compounds | en_US |
| e-ISSN | 1532-8503 | |
| Embargo date | 2030-12-31 | |
