| Author | Estanislau, Juliana de Assis Silva Gomes | |
| Author | Oliveira, Lilian Maria Garcia Bahia de | |
| Author | Rocha, Manoel Otávio da Costa | |
| Author | Busek, Solange Cristina Uber | |
| Author | Teixeira, Mauro Martins | |
| Author | Silva, João Santana da | |
| Author | Oliveira, Rodrigo Correa de | |
| Access date | 2013-10-15T12:55:22Z | |
| Available date | 2013-10-15T12:55:22Z | |
| Document date | 2006 | |
| Citation | GOMES, Juliana A. S. et al. Type 1 Chemokine Receptor Expression in Chagas' Disease Correlates with Morbidity in Cardiac Patients. Infect. Immun. 2005; 73(12): 7960-7966 | pt_BR |
| ISSN | 0019-9567 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7144 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Type 1 Chemokine Receptor Expression in Chagas' Disease Correlates with Morbidity in Cardiac Patients | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/IAI.73.12.7960-7966.2005 | |
| Abstract | Chemokines and chemokine receptors (CKRs) control the migration of leukocytes during the inflammatory process and are important immunological markers of type 1 (CCR5 and CXCR3) and type 2 (CCR3 and CCR4) responses. The coexpression of CKRs (CCR2, CCR3, CCR5, CXCR3, and CXCR4) and intracellular cytokines (interleukin-10 [IL-10], IL-4, tumor necrosis factor alpha [TNF-α], and gamma interferon [IFN-γ]) on T CD4+ and CD8+ peripheral cells from individuals with indeterminate (IND) or cardiac (CARD) clinical forms of Chagas' disease after in vitro stimulation with Trypanosoma cruzi antigens, were evaluated in this study. The percentage of T CD4+ and CD8+ cells coexpressing CCR5 and IFN-γ, CXCR3 and IFN-γ, and CXCR3 and TNF-α were higher in CARD than in IND individuals; on the other hand, the percentage of T CD4+ or CD8+ cells coexpressing CCR3 and IL-10 or coexpressing CCR3 and IL-4 were lower in CARD individuals than in IND individuals. In addition, a significant positive correlation between the expression of CCR5 or CXCR3 and IFN-γ was observed in CARD individuals contrasting with a significant positive correlation between the expression of CCR3 and IL-4 and of CCR3 and IL-10 in IND patients. These results reinforce the hypothesis that a T. cruzi-exacerbated specific type 1 immune response developed by CARD chagasic patients is associated with the development of heart pathology. | pt_BR |
| Affilliation | Fundação Oswaldo. Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ,, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-graduação em Medicina Tropical. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo. Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Imunologia. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo. Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | Chagas' disease | pt_BR |
| Subject | immune response | pt_BR |
