| Author | Takenami, Iukary Oliveira | |
| Author | Finkmoore, Brook | |
| Author | Machado Junior, Almério | |
| Author | Emodi, Krisztina | |
| Author | Riley, Lee Woodland | |
| Author | Arruda, Sérgio Marcos | |
| Access date | 2013-10-24T18:04:01Z | |
| Available date | 2013-10-24T18:04:01Z | |
| Document date | 2012 | |
| Citation | TAKENAMI, I. et el. Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. Pulmonary Medicine, p. 1-6, 2012. | pt_BR |
| ISSN | 2090-1844 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7201 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Title | Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2012/757152 | |
| Abstract | Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis
infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who
were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a followup
examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and
after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level
higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but
remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further
studies must be undertaken to understand if this elevation is transient. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USA | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Secretary of Health of Bahia State. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USA | pt_BR |
| Affilliation | University of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, Brasil /Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Secretary of Health of Bahia State. Salvador, BA, Brasil | pt_BR |
| DeCS | Mycobacterium tuberculosis | pt_BR |
| DeCS | Tuberculose latente | pt_BR |
| DeCS | Transmissao | pt_BR |
| DeCS | Teste tuberculínico | pt_BR |
