| Author | Pereira, Cíntia Aparecida de Jesus | |
| Author | Souza, Raquel Lopes Martins | |
| Author | Coelho, Paulo Marcos Zach | |
| Author | Lima, Walter dos Santos | |
| Author | Corrêa, Deborah Aparecida Negrão | |
| Access date | 2013-10-25T13:13:51Z | |
| Available date | 2013-10-25T13:13:51Z | |
| Document date | 2006 | |
| Citation | PEREIRA, Cíntia Aparecida de Jesus et al. Effect ofAngiostrongylus vasoruminfection onBiomphalaria tenagophilasusceptibility toSchistosoma mansoni. Acta Trop. 2006 Jul;98(3):224-33 | pt_BR |
| ISSN | 0001-706X | |
| URI | https://www.arca.fiocruz.br/handle/icict/7205 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Effect ofAngiostrongylus vasoruminfection onBiomphalaria tenagophilasusceptibility toSchistosoma mansoni. | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2006.05.002 | |
| Abstract | Concomitant infection with different parasites may be a helpful laboratorial strategy leading to the better understanding of the mechanisms used by the internal defense system (IDS) of Gastropoda to deal with helminth infection, such as Schistosoma mansoni. This work reports the effect of co-infection of Angiostrongylus vasorum and S. mansoni in hemocyte activity and in the outcome of infection. The simultaneous infection resulted in an increase of snail susceptibility to S. mansoni. In contrast, snails infected with both parasites, 15 days apart, did not show differences in the susceptibility compared to a single parasite infection. The increased susceptibility was measured by the significantly higher number of migrating sporocysts, higher percentage of snails shedding cercariae, higher number of cercariae shed and higher mortality in the experimental group that were simultaneously infected with A. vasorum and S. mansoni, when compared to snails infected only with S. mansoni. Snails simultaneously infected with A. vasorum and S. mansoni showed lower hemocyte activation during the first few days of infection, compared to activation induced only by A. vasorum infection. Between 5 and 15 days post-infection (dpi), granulocyte number and nitric oxide (NO) contents of simultaneously infected snails were lower than the S. mansoni-infected snails. Based on the results, we suggest that differences in the level of hemocyte response could explain the increased S. mansoni susceptibility observed in snails simultaneously infected with both parasites. However, when S. mansoni infection occurred after A. vasorum larvae are completely encapsulated, the response against S. mansoni was not altered, and therefore there were no differences in the susceptibility level. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil/Santa Casa de Misericordia de Belo Horizonte. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Biomphalaria tenagophila | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Angiostrongylus vasorum | pt_BR |
| Subject | Hemocyte activation | pt_BR |
| Subject | Internal defense system of molluscs | pt_BR |
