| Author | Cardoso, Cristiane Wanderley | |
| Author | Pinto, Lorene Louise Silva | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Flannery, Brendan | |
| Author | Reis, Joice Neves | |
| Access date | 2013-11-25T13:30:36Z | |
| Available date | 2013-11-25T13:30:36Z | |
| Document date | 2012 | |
| Citation | CARDOSO, C. W. et al. Impact of vaccination during an epidemic of serogroup C meningococcal disease in Salvador, Brazil. Vaccine, v. 30, n. 37, p.5541-5546, 2012. | pt_BR |
| ISSN | 0264-410X | |
| URI | https://www.arca.fiocruz.br/handle/icict/7256 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Ltd | pt_BR |
| Rights | open access | pt_BR |
| Title | Impact of vaccination during an epidemic of serogroup C meningococcal disease in Salvador, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1016/j.vaccine.2012.06.044 | |
| Abstract | To combat rising incidence of serogroup C meningococcal disease in the city of Salvador, Brazil, the Bahia
state immunization program initiated routine childhood immunization with meningococcal C conjugate
vaccine (MenC) in February 2010, followed by mass MenC vaccination of city residents 10–24 years of
age from May through August 2010. We analyzed trends in incidence of reported cases of meningococcal
disease and serogroup distribution among meningococcal isolates identified in hospital-based surveillance
in Salvador from January 2000 to December 2011 and estimated vaccine effectiveness using the
screening method. Annual incidence of serogroup C meningococcal disease increased from 0.1 cases per
100,000 population during 2000–2006 to 2.3 in 2009 and 4.1 in 2010, before falling to 2.0 per 100,000
in 2011. Estimated coverage of mass vaccination reached 80%, 67% and 41% among 10–14, 15–19 and
20–24 year olds, respectively. Incidence in 2011 was significantly lower than average rates in 2008–2009
among children <5 years, but reductions among 10–24 year olds were not significant. Among 10–24
year olds, a single dose of MenC vaccine was 100% effective (95% confidence interval, 79–100%) against
serogroup C meningococcal disease. Low coverage in the population targeted for mass vaccination may
have limited impact on ongoing transmission of serogroup C meningococcal disease despite high vaccine
effectiveness. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Research Center. Brazilian Ministry of Health. Salvador, Bahia, Brasil / Municipal Secretary of Health. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Secretary of Health for the State of Bahia. Salvador, Bahia, Brasil / Federal University of Bahia. School of Medicine. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Research Center. Brazilian Ministry of Health. Salvador, Bahia, Brasil / Municipal Secretary of Health. Salvador, Bahia, Brasil / Federal University of Bahia. School of Medicine. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Pan American Health Organization. Brasilia, DF, Brasil | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Research Center. Brazilian Ministry of Health. Salvador, Bahia, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, Brasil | pt_BR |
| Subject | Neisseria meningitidis | pt_BR |
| Subject | Meningococcal vaccine | pt_BR |
| Subject | Bacterial meningitis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
